Immunotherapy shows efficacy for multiple cancer types and potential for expanded use.
However, current immune checkpoint inhibitors (ICIs) are ineffective against microsatellite …

Diverse drug design strategies viz. molecular hybridization, substituent installation, scaffold
hopping, isosteric replacement, high-throughput screening, induction and separation of …

The integration of quantitative trait loci (QTL) with disease genome-wide association studies
(GWAS) has proven successful at prioritizing candidate genes at disease-associated loci …

The availability of patient cohorts with several types of omics data opens new perspectives
for exploring the disease's underlying biological processes and developing predictive …

Genome-wide association studies (GWAS) have identified more than 200 common genetic
variants independently associated with colorectal cancer (CRC) risk, but the causal variants …

Background While circulating metabolites have been increasingly linked to cancer risk, the
causality underlying these associations remains largely uninterrogated. Methods We …

Background Transcriptome-wide association studies have been successful in identifying
candidate susceptibility genes for colorectal cancer (CRC). To strengthen susceptibility gene …

Several observational studies have revealed an association between autoimmune diseases
(AIDs) and colorectal cancer (CRC), although their causal association remained …

Large-scale genetic studies are reliably identifying many risk factors for disease in the
general population. Several of these genetic risk factors encode potential drug targets, and …

Background Hereditary factors, including single genetic variants and family history, can be
used for targeting colorectal cancer (CRC) screening, but limited data exist on the impact of …