The tumor microenvironment (TME) is emerging as one of the primary barriers in cancer
therapy. Cancer-associated fibroblasts (CAF) are a common inhabitant of the TME in several …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a prominent extracellular
matrix (ECM) deposition and poor prognosis. High levels of ECM proteins derived from …

Stromal desmoplastic reaction in pancreatic ductal adenocarcinoma (PDAC) involves
significant accumulation of type I collagen (Col1). However, the precise molecular and …

Despite recent efforts to dissect the inter-tumor heterogeneity of pancreatic ductal
adenocarcinoma (PDAC) by determining prognosis-predictive gene expression signatures …

Lipids are essential constituents for malignant tumors, as they are absolutely required for
tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by …

The poor clinical outcome in pancreatic ductal adenocarcinoma (PDA) is attributed to
intrinsic chemoresistance and a growth-permissive tumor microenvironment. Conversion of …

Pancreatic ductal adenocarcinoma (PDAC) has an extraordinarily dense fibrotic stroma that
impedes tumor perfusion and delivery of anticancer drugs. Since the extracellular matrix …

Although fibrosis is a common pathological feature of most end-stage organ diseases, its
pathogenesis remains unclear. There is growing evidence that mitochondrial dysfunction …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related morbidity
and mortality in the western world, with limited therapeutic strategies and dismal long-term …