The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

The phylum Nucleocytoviricota includes the largest and most complex viruses known. These
“giant viruses” have a long evolutionary history that dates back to the early diversification of …

Gasdermins comprise a family of pore-forming proteins, which play critical roles in (auto)
inflammatory diseases and cancer. They are expressed as self-inhibited precursor proteins …

The plant homolog of vertebrate necroptosis inducer mixed-lineage kinase domain-like
(MLKL) contributes to downstream steps in Toll-interleukin-1 receptor domain NLR (TNL) …

Diverse inflammatory conditions, from infections to autoimmune disease, are often
associated with cellular damage and death. Apoptotic cell death has evolved to minimize its …

Necroptosis is a lytic form of programmed cell death implicated in inflammatory pathologies,
leading to intense interest in the underlying mechanisms and therapeutic prospects. Here …

Human norovirus is the leading cause of acute gastroenteritis worldwide, however despite
the significance of this pathogen, we have a limited understanding of how noroviruses cause …

Intestinal epithelial cell (IEC) responses to interferon (IFN) favor antiviral defense with
minimal cytotoxicity, but IEC-specific factors that regulate these responses remain poorly …

Host control over infectious disease relies on the ability of cells in multicellular organisms to
detect and defend against pathogens to prevent disease. Evolution affords mammals with a …

Cell membrane is crucial for the cellular activities, and any disruption to it may affect the
cells. It is demonstrated that cell membrane perforation is associated with some biological …