Strategies to improve the EPR effect: A mechanistic perspective and clinical translation
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …
their efficacy and to reduce their adverse effects. These efforts include the development of …
Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives
The microenvironment characteristics of solid tumors, renowned as barriers that harshly
impeded many drug-delivery approaches, were precisely studied, investigated, categorized …
impeded many drug-delivery approaches, were precisely studied, investigated, categorized …
Emerging nanotechnological approaches to regulating tumor vasculature for cancer therapy
Abnormal angiogenesis stands for one of the most striking manifestations of malignant
tumor. The pathologically and structurally abnormal tumor vasculature facilitates a hostile …
tumor. The pathologically and structurally abnormal tumor vasculature facilitates a hostile …
Modulating the tumor microenvironment to enhance tumor nanomedicine delivery
B Zhang, Y Hu, Z Pang - Frontiers in pharmacology, 2017 - frontiersin.org
Nanomedicines including liposomes, micelles, and nanoparticles based on the enhanced
permeability and retention (EPR) effect have become the mainstream for tumor treatment …
permeability and retention (EPR) effect have become the mainstream for tumor treatment …
Nano-engineered mesenchymal stem cells increase therapeutic efficacy of anticancer drug through true active tumor targeting
Tumor-targeted drug delivery has the potential to improve therapeutic efficacy and mitigate
non-specific toxicity of anticancer drugs. However, current drug delivery approaches rely on …
non-specific toxicity of anticancer drugs. However, current drug delivery approaches rely on …
Approaches to improve EPR-based drug delivery for cancer therapy and diagnosis
The innovative development of nanomedicine has promised effective treatment options
compared to the standard therapeutics for cancer therapy. However, the efficiency of EPR …
compared to the standard therapeutics for cancer therapy. However, the efficiency of EPR …
Anti-lymphangiogenesis for boosting drug accumulation in tumors
The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current
therapeutic drugs and remains an even more significant concern in the clinical prospects for …
therapeutic drugs and remains an even more significant concern in the clinical prospects for …
Precise fibrin decomposition and tumor mechanics modulation with hydroxyethyl starch-based smart nanomedicine for enhanced antitumor efficacy
J Chen, Z Zhang, Y Li, H Zeng, Z Li, C Wang… - Journal of Materials …, 2022 - pubs.rsc.org
Chemotherapy is a conventional cancer treatment in clinical settings. Although numerous
nano drug delivery systems have been developed, the chemotherapeutic effect is greatly …
nano drug delivery systems have been developed, the chemotherapeutic effect is greatly …
PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models
L Morosi, M Meroni, P Ubezio, I Fuso Nerini… - Journal of Experimental …, 2021 - Springer
Background Scarce drug penetration in solid tumours is one of the possible causes of the
limited efficacy of chemotherapy and is related to the altered tumour microenvironment. The …
limited efficacy of chemotherapy and is related to the altered tumour microenvironment. The …
Stromal disruption facilitating invasion of a 'nano-arsenal'into the solid tumor
Owing to the indispensable role of nanotechnology in cancer therapy, it is imperative to
comprehend every aspect limiting its therapeutic potential. Several preclinical reports have …
comprehend every aspect limiting its therapeutic potential. Several preclinical reports have …