The market for large molecule biologic drugs has grown rapidly, including antisense
oligonucleotide (ASO) drugs. ASO drugs work as single-stranded synthetic oligonucleotides …

Atherosclerotic cardiovascular disease (ASCVD) is epidemic throughout the world and is
etiologic for such acute cardiovascular events as myocardial infarction, ischemic stroke …

Systemic diseases of liver origin (SDLO) are complex diseases in multiple organ systems,
such as cardiovascular, musculoskeletal, endocrine, renal, respiratory, and sensory organ …

Familial hypercholesterolemia (FH) is the most common genetic disorder of lipid
metabolism, affecting almost 1 in 25 0 individuals worldwide. It is usually inherited via the …

Background Familial hypercholesterolaemia (FH) is a genetic disease characterised by
hypercholesterolaemia and premature cardiovascular events. Early diagnosis and treatment …

The efficacy of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition has
broadened lipid-lowering therapy thus providing decreased risk in atherosclerotic …

The exponential expansion of genomic data coupled with the lack of appropriate clinical
categorization of the variants is posing a major challenge to conventional medications for …

Achilles tendon xanthoma (ATX) formation involves macrophage cholesterol accumulation
within the tendon, similar to that occurring in atheroma. Macrophage cholesterol …

Abstract Objective Familial Hypercholesterolemia (FH) is an inherited disorder leading to
increased risk of premature atherosclerotic cardiovascular disease. This risk can be …

Aims Despite intensive lipid-lowering therapies (LLTs), most patients with homozygous
familial hypercholesterolaemia (HoFH) do not achieve guideline recommended low-density …