Pathophysiological mechanisms of liver injury in COVID‐19

AD Nardo, M Schneeweiss‐Gleixner… - Liver …, 2021 - Wiley Online Library
The recent outbreak of coronavirus disease 2019 (COVID‐19), caused by the Severe Acute
Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) has resulted in a world‐wide …

COVID-19 and multiorgan failure: A narrative review on potential mechanisms

T Mokhtari, F Hassani, N Ghaffari, B Ebrahimi… - Journal of molecular …, 2020 - Springer
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in
December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) …

Liver injury during highly pathogenic human coronavirus infections

L Xu, J Liu, M Lu, D Yang, X Zheng - Liver international, 2020 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐Cov‐2), the pathogen of 2019
novel coronavirus disease (COVID‐19), has posed a serious threat to global public health …

Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection

X Chai, L Hu, Y Zhang, W Han, Z Lu, A Ke, J Zhou… - biorxiv, 2020 - biorxiv.org
A newly identified coronavirus, 2019-nCoV, has been posing significant threats to public
health since December 2019. ACE2, the host cell receptor for severe acute respiratory …

[PDF][PDF] Single‐cell, single‐nucleus, and spatial RNA sequencing of the human liver identifies cholangiocyte and mesenchymal heterogeneity

TS Andrews, J Atif, JC Liu, CT Perciani… - Hepatology …, 2022 - Wiley Online Library
The critical functions of the human liver are coordinated through the interactions of hepatic
parenchymal and non‐parenchymal cells. Recent advances in single‐cell transcriptional …

Inflammation triggered by SARS-CoV-2 and ACE2 augment drives multiple organ failure of severe COVID-19: molecular mechanisms and implications

M Iwasaki, J Saito, H Zhao, A Sakamoto, K Hirota, D Ma - Inflammation, 2021 - Springer
The widespread occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) has led to a pandemic of coronavirus disease 2019 (COVID-19). The S spike protein …

Coronaviruses pathogenesis, comorbidities and multi-organ damage–A review

K Renu, PL Prasanna, AV Gopalakrishnan - Life sciences, 2020 - Elsevier
Abstract Human coronaviruses, especially COVID-19, is an emerging pandemic infectious
disease with high morbidity and mortality. Coronaviruses are associated with comorbidities …

Oxidative stress in liver pathophysiology and disease

A Allameh, R Niayesh-Mehr, A Aliarab, G Sebastiani… - Antioxidants, 2023 - mdpi.com
The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …

Single-cell technologies in hepatology: new insights into liver biology and disease pathogenesis

P Ramachandran, KP Matchett, R Dobie… - Nature reviews …, 2020 - nature.com
Liver disease is a major global health-care problem, affecting an estimated 844 million
people worldwide. Despite this substantial burden, therapeutic options for liver disease …

Liver injury is associated with severe coronavirus disease 2019 (COVID‐19) infection: a systematic review and meta‐analysis of retrospective studies

M Parohan, S Yaghoubi, A Seraji - Hepatology Research, 2020 - Wiley Online Library
The coronavirus disease 2019 (COVID‐19) outbreak is a major threat to human beings.
Lung injury has been reported as the major outcome of COVID‐19 infection. However, liver …