Experimental in vitro, ex vivo and in vivo models in prostate cancer research

V Sailer, G von Amsberg, S Duensing, J Kirfel… - Nature Reviews …, 2023 - nature.com
Androgen deprivation therapy has a central role in the treatment of advanced prostate
cancer, often causing initial tumour remission before increasing independence from signal …

Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

Recent advances in thyroid cancer research

D Grimm - International Journal of Molecular Sciences, 2022 - mdpi.com
This Special Issue (SI)“Recent Advances in Thyroid Cancer Research” covers research
articles and reviews in the field of thyroid cancer research. It includes publications reporting …

Extraterrestrial gynecology: could spaceflight increase the risk of developing cancer in female astronauts? An updated review

R Drago-Ferrante, R Di Fiore, F Karouia… - International journal of …, 2022 - mdpi.com
Outer space is an extremely hostile environment for human life, with ionizing radiation from
galactic cosmic rays and microgravity posing the most significant hazards to the health of …

Decellularized plant-derived vasculature-on-a-chip interacting with breast cancer spheroids to evaluate a dual-drug therapy

Y Filiz, Y Arslan, E Duran, P Saglam-Metiner… - Applied Materials …, 2024 - Elsevier
Breast cancer progression is a complex process involving the primary tumor and its
microenvironment supported by a vascular network. Multicellular spheroids closely mimic in …

Impairment of 7F2 osteoblast function by simulated partial gravity in a Random Positioning Machine

J Braveboy-Wagner, PI Lelkes - NPJ microgravity, 2022 - nature.com
The multifaceted adverse effects of reduced gravity pose a significant challenge to human
spaceflight. Previous studies have shown that bone formation by osteoblasts decreases …

Simulated microgravity influences immunity-related biomarkers in lung cancer

H Baghoum, H Alahmed, M Hachim, A Senok… - International Journal of …, 2022 - mdpi.com
Microgravity is a novel strategy that may serve as a complementary tool to develop future
cancer therapies. In lung cancer, the influence of microgravity on cellular processes and the …

3D-Printed Tumor-on-a-Chip Model for Investigating the Effect of Matrix Stiffness on Glioblastoma Tumor Invasion

M Amereh, A Seyfoori, B Dallinger, M Azimzadeh… - Biomimetics, 2023 - mdpi.com
Glioblastoma multiform (GBM) tumor progression has been recognized to be correlated with
extracellular matrix (ECM) stiffness. Dynamic variation of tumor ECM is primarily regulated …

Long-term simulation of microgravity induces changes in gene expression in breast cancer cells

J Sahana, JL Cortés-Sánchez, V Sandt… - International Journal of …, 2023 - mdpi.com
Microgravity changes the gene expression pattern in various cell types. This study focuses
on the breast cancer cell lines MCF-7 (less invasive) and MDA-MB-231 (triple-negative …

Metabolomics Profile of the Secretome of Space-Flown Oligodendrocytes

L Vergnes, B Foucaud, C Cepeda, A Espinosa-Jeffrey - Cells, 2023 - mdpi.com
Intracranial hypertension (ICP) and visual impairment intracranial pressure (VIIP) are some
of the sequels of long-term space missions. Here we sought to determine how space …