RNA modifications: importance in immune cell biology and related diseases

L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

Role of main RNA modifications in cancer: N6-methyladenosine, 5-methylcytosine, and pseudouridine

C Xue, Q Chu, Q Zheng, S Jiang, Z Bao, Y Su… - Signal transduction and …, 2022 - nature.com
Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

N6-methyladenosine reader IMP2 stabilizes the ZFAS1/OLA1 axis and activates the Warburg effect: implication in colorectal cancer

S Lu, L Han, X Hu, T Sun, D Xu, Y Li, Q Chen… - Journal of Hematology & …, 2021 - Springer
Background Accumulating evidence shows that N6-methyladenine (m 6 A) modulators
contribute to the etiology and progression of colorectal cancer (CRC). However, the exact …

Pan-cancer analysis shows that ALKBH5 is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including gliomas

C Wei, B Wang, D Peng, X Zhang, Z Li, L Luo… - Frontiers in …, 2022 - frontiersin.org
Background AlkB homolog 5 (ALKBH5) is a N6-methyladenosine (m6A) demethylase
associated with the development, growth, and progression of multiple cancer types …

Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance

H Lin, Y Wang, P Wang, F Long, T Wang - Molecular cancer, 2022 - Springer
The resistance of tumor cells to therapy severely impairs the efficacy of treatment, leading to
recurrence and metastasis of various cancers. Clarifying the underlying mechanisms of …

N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway

P Wu, X Fang, Y Liu, Y Tang, W Wang, X Li… - Cell Death & …, 2021 - nature.com
Hypopharyngeal squamous cell carcinoma (HPSCC) is one of the most common malignant
tumors in otolaryngology head and neck surgery and is one of the worst prognostic …

The evolving landscape of N6-methyladenosine modification in the tumor microenvironment

Y Gu, X Wu, J Zhang, Y Fang, Y Pan, Y Shu, P Ma - Molecular Therapy, 2021 - cell.com
The tumor microenvironment (TME), controlled by intrinsic mechanisms of carcinogenesis
and epigenetic modifications, has, in recent years, become a heavily researched topic. The …

Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in …

C Ding, X Yi, X Chen, Z Wu, H You, X Chen… - Journal of Experimental …, 2021 - Springer
Background Temozolomide (TMZ) resistance limits its application in glioma. Exosome can
carry circular RNAs (circRNAs) to regulate drug resistance via sponging microRNAs …

LNCAROD enhances hepatocellular carcinoma malignancy by activating glycolysis through induction of pyruvate kinase isoform PKM2

G Jia, Y Wang, C Lin, S Lai, H Dai, Z Wang… - Journal of Experimental …, 2021 - Springer
Background Mounting evidence has suggested the essential role of long non-coding RNAs
(lncRNAs) in a plethora of malignant tumors, including hepatocellular carcinoma. However …

[HTML][HTML] N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability

H Yu, K Zhao, H Zeng, Z Li, K Chen, Z Zhang… - Biomedicine & …, 2021 - Elsevier
Abstract N 6-methyladenosine (m 6 A) is one of the most abundant messenger RNAs
modification. Increasing evidence illustrates its critical role on gastric cancer. Here, present …