Chronic hepatitis B virus (HBV) infection is a dynamic process involving interactions among
HBV, hepatocytes, and the host immune system. The natural course of chronic hepatitis B …

There have been unprecedented advances in the identification of new treatment targets for
chronic hepatitis B that are being developed with the goal of achieving functional cure in …

Hepatitis B virus (HBV) remains a major cause of morbidity and mortality worldwide.
Treatments that can induce functional cure in patients chronically infected with this …

Background & Aim Antiviral therapy has greatly improved the outcomes of patients with
chronic hepatitis B virus (HBV) infection and active liver disease or advanced …

Background & Aims Production of neutralizing antibodies against hepatitis B surface antigen
(HBsAg) is dysregulated in patients with persistent hepatitis B virus (HBV) infection. We …

Immune checkpoint proteins programmed death-1 (PD-1) and T-cell immunoglobulin
domain and mucin domain containing molecule-3 (TIM-3) expression and their gene …

The hepatitis B virus (HBV) is a major cause of cirrhosis and hepatocellular carcinoma
worldwide. Despite an effective vaccine, the prevalence of chronic infection remains high …

Chronic hepatitis B (CHB) is the most common cause of hepatocellular carcinoma (HCC)
worldwide. Antiviral treatment reduces the risk of HCC and mortality; nonetheless, globally in …

In diverse viral infections, the production of excess viral particles containing only viral
glycoproteins (subviral particles or SVP) is commonly observed and is a commonly evolved …

The impaired T cell responses observed in chronic hepatitis B (HBV) patients are
considered to contribute to the chronicity of the infection. Research on this impairment has …