Gliflozins in the management of cardiovascular disease

E Braunwald - New England Journal of Medicine, 2022 - Mass Medical Soc
Gliflozins in Cardiac and Renal Disease Gliflozins—sodium–glucose cotransporter 2
inhibitors—lower blood glucose and glycated hemoglobin in patients with type 2 diabetes …

Worsening Heart Failure: Nomenclature, Epidemiology, and Future Directions: JACC Review Topic of the Week

SJ Greene, J Bauersachs, JJ Brugts… - Journal of the American …, 2023 - jacc.org
Heart failure (HF) is a progressive disease characterized by variable durations of
symptomatic stability often punctuated by episodes of worsening despite continued therapy …

Effect of empagliflozin on worsening heart failure events in patients with heart failure and preserved ejection fraction: EMPEROR-preserved trial

M Packer, J Butler, F Zannad, G Filippatos, JP Ferreira… - Circulation, 2021 - Am Heart Assoc
Background: Empagliflozin reduces the risk of cardiovascular death or hospitalization for
heart failure in patients with heart failure with preserved ejection fraction, but additional data …

Effect of empagliflozin on the clinical stability of patients with heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial

M Packer, SD Anker, J Butler, G Filippatos, JP Ferreira… - Circulation, 2021 - Am Heart Assoc
Background: Empagliflozin reduces the risk of cardiovascular death or hospitalization for
heart failure in patients with heart failure and a reduced ejection fraction, with or without …

Worsening of chronic heart failure: Definition, epidemiology, management and prevention. A clinical consensus statement by the Heart Failure Association of the …

M Metra, D Tomasoni, M Adamo… - European Journal of …, 2023 - Wiley Online Library
Episodes of worsening symptoms and signs characterize the clinical course of patients with
chronic heart failure (HF). These events are associated with poorer quality of life, increased …

Efficacy and safety of dapagliflozin in men and women with heart failure with reduced ejection fraction: a prespecified analysis of the dapagliflozin and prevention of …

JH Butt, KF Docherty, MC Petrie, M Schou… - JAMA …, 2021 - jamanetwork.com
Importance Women may respond differently to certain treatments for heart failure (HF) with
reduced ejection fraction (HFrEF) than men. Objective To investigate the efficacy and safety …

Sodium–glucose transporter-2 inhibitors for prevention and treatment of cardiorenal complications of type 2 diabetes

D Giugliano, M Longo, L Scappaticcio… - Cardiovascular …, 2021 - Springer
Hospitalization for major diabetes complications, including myocardial infarction, stroke,
lower-extremity amputation, and end-stage kidney disease, is on the rise and represents a …

Effect of empagliflozin on heart failure outcomes after acute myocardial infarction: insights from the EMPACT-MI trial

AF Hernandez, JA Udell, WS Jones, SD Anker… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Empagliflozin reduces the risk of heart failure (HF) events in patients with
type 2 diabetes at high cardiovascular risk, chronic kidney disease, or prevalent HF …

Systematic review of sodium‐glucose cotransporter 2 inhibitors: a hopeful prospect in tackling heart failure‐related events

B Aziri, E Begic, S Jankovic, Z Mladenovic… - ESC Heart …, 2023 - Wiley Online Library
In modern cardiology, sodium‐glucose cotransporter 2 (SGLT2) inhibitors are critical
components of heart failure (HF) treatment algorithms and exert their effects primarily by …

Empagliflozin and left ventricular remodeling in people without diabetes: primary results of the EMPA-HEART 2 CardioLink-7 randomized clinical trial

KA Connelly, CD Mazer, P Puar, H Teoh, CH Wang… - Circulation, 2023 - Am Heart Assoc
Background: Sodium-glucose cotransporter 2 inhibitors have been demonstrated to promote
reverse cardiac remodeling in people with diabetes or heart failure. Although it has been …