The Omicron variant of concern: Diversification and convergent evolution in spike protein, and escape from anti-Spike monoclonal antibodies

D Focosi, S McConnell, A Casadevall - Drug Resistance Updates, 2022 - Elsevier
Abstract WHO-defined SARS-CoV-2 variants of concern (VOC) drive therapeutics and
vaccine development. The Omicron VOC is dominating the arena since November 2021, but …

[HTML][HTML] Omicron variant: Current insights and future directions

R Rana, R Kant, RS Huirem, D Bohra… - Microbiological …, 2022 - Elsevier
The global COVID-19 outbreak has returned with the identification of the SARS-CoV-2
Omicron variant (B. 1.1. 529) after appearing to be persistently spreading for the more than …

Omicron variant (B. 1.1. 529): infectivity, vaccine breakthrough, and antibody resistance

J Chen, R Wang, NB Gilby, GW Wei - Journal of chemical …, 2022 - ACS Publications
The latest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant Omicron
(B. 1.1. 529) has ushered panic responses around the world due to its contagious and …

SARS-CoV-2 spike mutations, L452R, T478K, E484Q and P681R, in the second wave of COVID-19 in Maharashtra, India

S Cherian, V Potdar, S Jadhav, P Yadav, N Gupta… - Microorganisms, 2021 - mdpi.com
As the global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic
expands, genomic epidemiology and whole genome sequencing are being used to …

Omicron BA. 2 (B. 1.1. 529.2): high potential for becoming the next dominant variant

J Chen, GW Wei - The journal of physical chemistry letters, 2022 - ACS Publications
The Omicron variant has three subvariants: BA. 1 (B. 1.1. 529.1), BA. 2 (B. 1.1. 529.2), and
BA. 3 (B. 1.1. 529.3). BA. 2 is found to be able to alarmingly reinfect patients originally …

Mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America

R Wang, J Chen, GW Wei - The journal of physical chemistry …, 2021 - ACS Publications
The importance of understanding SARS-CoV-2 evolution cannot be overlooked. Recent
studies confirm that natural selection is the dominating mechanism of SARS-CoV-2 …

Emerging vaccine-breakthrough SARS-CoV-2 variants

R Wang, J Chen, Y Hozumi, C Yin… - ACS infectious …, 2022 - ACS Publications
The surge of COVID-19 infections has been fueled by new SARS-CoV-2 variants, namely
Alpha, Beta, Gamma, Delta, and so forth. The molecular mechanism underlying such surge …

Persistent Laplacian projected Omicron BA. 4 and BA. 5 to become new dominating variants

J Chen, Y Qiu, R Wang, GW Wei - Computers in Biology and Medicine, 2022 - Elsevier
Due to its high transmissibility, Omicron BA. 1 ousted the Delta variant to become a
dominating variant in late 2021 and was replaced by more transmissible Omicron BA. 2 in …

[HTML][HTML] A systematic review of vaccine breakthrough infections by SARS-CoV-2 delta variant

M Zhang, Y Liang, D Yu, B Du, W Cheng… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
Vaccines are proving to be highly effective in controlling hospitalization and deaths
associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

[HTML][HTML] Covid-19: virology, variants, and vaccines

M Young, H Crook, J Scott, P Edison - BMJ medicine, 2022 - ncbi.nlm.nih.gov
Abstract As of 25 January 2022, over 349 million individuals have received a confirmed
diagnosis of covid-19, with over 5.59 million confirmed deaths associated with the SARS …