Overweight, obesity, and type 2 diabetes mellitus pose global health problems that are ever-
increasing. A chronic low-grade inflammatory status and the presence of various pro …

Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and
pancreatic β-cell dysfunction, which result from the interplay of local abnormalities within …

Background Increasing evidence from observational studies and clinical experimentation
has indicated a link between the gut microbiotas (GMs) and polycystic ovary syndrome …

We conduct proteome-wide Mendelian randomization and colocalization analyses to
decipher the associations of blood proteins with the risk of type 2 diabetes and diabetic …

Background Previous evidence suggests a link between gut microbiota and chronic pain,
but the causal relationship is not yet fully understood. Methods We categorized gut …

The causes of neurodegenerative diseases remain largely elusive, increasing their personal
and societal impacts. To reveal the causal effects of iron load on Parkinson's disease (PD) …

Background Observational studies have revealed that metabolic disorders are closely
related to the development of preeclampsia (PE). However, there is still a research gap on …

Precision diabetes medicine (PDM) aims to reduce errors in prevention programmes,
diagnosis thresholds, prognosis prediction and treatment strategies. However, its …

Introduction: Observational studies have shown that obesity is a risk factor for various
autoimmune diseases. However, the causal relationship between obesity and autoimmune …

Aim Mendelian randomization (MR) analysis has been used in the exploration of the role of
gut microbiota (GM) in type 2 diabetes mellitus (T2DM); however, it was limited to the genus …