Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is cause of the novel
coronavirus disease (COVID-19). In the last two years, SARS-CoV-2 has infected millions of …

The COVID-19 pandemic has affected millions of people and posed an unprecedented
burden on healthcare systems and economies worldwide since the outbreak of the COVID …

Backgrounds SARS-CoV-2 infection results in a broad spectrum of clinical outcomes,
ranging from asymptomatic to severe symptoms and death. Most COVID-19 pathogenesis is …

Spleen tyrosine kinase (SYK) is a previously unidentified therapeutic target that inhibits
neutrophil and macrophage activation in coronavirus disease 2019 (COVID-19) …

Some physicians use dapsone as part of the standard treatment of severe COVID-19
patients entering the ICU, though some do not. To obtain an indication of whether dapsone …

Previous studies on paracoccidioidomycosis (PCM), the most prevalent systemic mycosis in
Latin America, revealed that host immunity is tightly regulated by several suppressive …

The oral cavity presents a diverse microbiota in a dynamic balance with the host. Disruption
of the microbial community can promote dysregulation of local immune response which …

Summary High interleukin (IL)-6 levels are associated with greater COVID-19 severity. IL-6
receptor blockade by tocilizumab (anti-IL6R; Actemra) is used globally for the treatment of …

Viral pneumonia is a global health burden with a high mortality rate, especially in the elderly
and in patients with underlying diseases. Recent studies have found that myeloid-derived …

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
cells capable of inhibiting T-cell responses. MDSCs have a crucial role in the regulation of …