Taxon-specific proteins are key determinants defining the biology of all organisms and
represent prime drug targets in pathogens. However, lacking comparability with proteins in …

There is a pressing need for new medicines to prevent and treat malaria. Most antimalarial
drug discovery is reliant upon phenotypic screening. However, with the development of …

Malaria remains one of the most perilous vector-borne infectious diseases for humans
globally. Sexual gametocyte represents the exclusive stage at which malaria parasites are …

Clustered Regions of Interspersed Palindromic Repeat (CRISPR)-based techniques have
been utilized in various research areas, including agriculture, biotechnology, and medicine …

Malaria, one of the major infectious diseases in the world, is caused by the Plasmodium
parasite. Plasmodium antigens could modulate the inflammatory response by binding to …

Babesiosis is an emerging zoonosis and widely distributed veterinary infection caused by
100+ species of Babesia parasites. The diversity of Babesia parasites and the lack of …

Genetic editing is a powerful tool for functional characterization of genes in various
organisms. With its simplicity and specificity, the CRISPR-Cas9 technology has become a …

The CRISPR mechanism, discovered in bacteria and archaea, operates as an adaptative
immune system at the genetic level. By using repetitive sequences, spacers derived from …

Many Plasmodium genes remain uncharacterised due to low genetic tractability. Previous
large scale knockout screens have only been able to target about half of the genome in the …

Meiosis is sexual cell division, a process in eukaryotes whereby haploid gametes are
produced. Compared to canonical model eukaryotes, meiosis in apicomplexan parasites …