Sulfhydryl chemistry plays a vital role in normal biology and in defense of cells against
oxidants, free radicals, and electrophiles. Modification of critical cysteine residues is an …

Oxidative stress, particularly reactive oxygen species (ROS), are important for innate
immunity against pathogens. ROS directly attack pathogens, regulate and amplify immune …

The lung is a delicate organ with a large surface area that is continuously exposed to the
external environment, and is therefore highly vulnerable to exogenous sources of oxidative …

Activation of the NLRP3 inflammasome by microbial ligands or tissue damage requires
intracellular generation of reactive oxygen species (ROS). We present evidence that …

Cannabinoids, mainly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), are the most
studied group of compounds obtained from Cannabis sativa because of their several …

Purinergic signaling is a cell communication pathway mediated by extracellular nucleotides
and nucleosides. Tri-and diphosphonucleotides are released in physiological and …

Oxidative stress is thought to play a key role in the development of intestinal damage in
inflammatory bowel disease (IBD), because of its primary involvement in intestinal cells' …

Abstract Hydrogen peroxide (H2O2) has a major function in host-microbial interactions.
Although most studies have focused on the endogenous H2O2 produced by immune cells to …

S100A8 and S100A9 are cytoplasmic proteins expressed by phagocytes. High
concentrations of these proteins have been correlated with various inflammatory conditions …

Viroporins are virus encoded proteins that alter membrane permeability and can trigger
subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a …