Liver fibrosis is the final common pathway of chronic or iterative liver damage. Advanced
chronic fibrosis is described as cirrhosis with a loss of architecture and attendant functional …

The liver has been studied extensively due to the broad number of diseases affecting its vital
functions. However, therapeutic advances have been hampered by the lack of knowledge …

In vitro three-dimensional (3D) cultures are emerging as novel systems with which to study
tissue development, organogenesis and stem cell behavior ex vivo. When grown in a 3D …

The liver is an organ that performs a multitude of functions, and its health is pertinent and
indispensable to survival. Thus, the cellular and molecular machinery driving hepatic …

Liver regeneration has been studied for many decades and the mechanisms underlying
regeneration of the normal liver following resection or moderate damage are well described …

Acute-on-chronic liver failure (ACLF) is a distinct clinical entity and differs from acute liver
failure and decompensated cirrhosis in timing, presence of acute precipitant, course of …

Liver injury results in rapid regeneration through hepatocyte proliferation and hypertrophy.
However, after acute severe injury, such as acetaminophen poisoning, effective …

The liver can substantially regenerate after injury, with both main epithelial cell types,
hepatocytes and biliary epithelial cells (BECs), playing important roles in parenchymal …

Signals related to liver regeneration (LR) have been identified by triggering proliferation in
hepatocyte cultures, delay of regeneration associated with signal ablation in genomically …

Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by
large amounts of extracellular matrix, which may lead to organ dysfunction and even death …