Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by lipid
accumulation in hepatocytes in the absence of excessive alcohol consumption. The global …

Cancer cells can use existing blood vessels to acquire a vasculature. This process is termed
'vessel co-option'. Vessel co-option is an alternative to the growth of new blood vessels, or …

Chronic liver injuries lead to liver fibrosis and then to end-stage liver cirrhosis. Liver
transplantation is often needed as a course of treatment for patients in critical conditions, but …

Receptor tyrosine kinases MET and epidermal growth factor receptor (EGFR) are critically
involved in initiation of liver regeneration. Other cytokines and signaling molecules also …

Emerging evidence suggests that hepatocytes are primarily maintained by self-renewal
during normal liver homeostasis, as well as in response to a wide variety of hepatic injuries …

The prognosis of cholangiocarcinoma (CC) is dismal. Notch has been identified as a
potential driver; forced exogenous overexpression of Notch1 in hepatocytes results in the …

Photo electron/energy transfer-reversible addition–fragmentation chain transfer (PET-RAFT)
has emerged as a powerful reversible-deactivation radical polymerization technique …

Background & Aim Chronic liver diseases are characterized by expansion of the small
immature cholangiocytes–a mechanism named ductular reaction (DR)–which have the …

The extrahepatic branches of the biliary tree have glands that connect to the surface
epithelium through narrow pits. The duct epithelia undergo homeostatic renewal, yet the …

Liver is one of the most common sites of cancer metastasis. Once disseminated, the
prognosis is poor as these tumors often display generalized chemoresistance, particularly …