The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential
structural component of a virion and facilitates many crucial life cycle steps through …

The HIV-1 capsid, composed of approximately 1,200 copies of the capsid protein, encases
genomic RNA alongside viral nucleocapsid, reverse transcriptase, and integrase proteins …

Summary Human immunodeficiency virus (HIV-1) remains a major health threat. Viral capsid
uncoating and nuclear import of the viral genome are critical for productive infection. The …

Abstract Lissencephaly-1 (Lis1) is a key cofactor for dynein-mediated intracellular transport
towards the minus-ends of microtubules. It remains unclear whether Lis1 serves as an …

Human immunodeficiency virus-1 capsid (HIV-1 CA) is involved in different stages of the
viral replication cycle. During virion assembly, CA drives the formation of the hexameric …

HIV-1 employs a rich arsenal of viral factors throughout its life cycle and co-opts intracellular
trafficking pathways. This exquisitely coordinated process requires precise manipulation of …

Nephrolithiasis is highly prevalent and associated with the increased risk of kidney cancer.
The tumor suppressor von Hippel-Lindau (VHL) is critical for renal cancer development …

HIV-1 uses the microtubule network to traffic the viral capsid core toward the nucleus. Viral
nuclear trafficking and infectivity require the kinesin-1 adaptor protein FEZ1. Here, we …

Microtubules (MTs) form a filamentous array that provide both structural support and a
coordinated system for the movement and organization of macromolecular cargos within the …

Mutations causing dysfunction of tubulins and microtubule-associated proteins, also known
as tubulinopathies, are a group of recently described entities that lead to complex brain …