Clinical implications of T cell exhaustion for cancer immunotherapy
A Chow, K Perica, CA Klebanoff… - Nature reviews Clinical …, 2022 - nature.com
Immunotherapy has been a remarkable clinical advancement in the treatment of cancer. T
cells are pivotal to the efficacy of current cancer immunotherapies, including immune …
cells are pivotal to the efficacy of current cancer immunotherapies, including immune …
Impact of the Human Cell Atlas on medicine
JE Rood, A Maartens, A Hupalowska, SA Teichmann… - Nature medicine, 2022 - nature.com
Single-cell atlases promise to provide a 'missing link'between genes, diseases and
therapies. By identifying the specific cell types, states, programs and contexts where disease …
therapies. By identifying the specific cell types, states, programs and contexts where disease …
Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial
There is a pressing need for allogeneic chimeric antigen receptor (CAR)-immune cell
therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord …
therapies that are safe, effective and affordable. We conducted a phase 1/2 trial of cord …
Hallmarks of CD8+ T cell dysfunction are established within hours of tumor antigen encounter before cell division
MW Rudloff, P Zumbo, NR Favret, JJ Roetman… - Nature …, 2023 - nature.com
Tumor-specific CD8+ T cells (TST) in patients with cancer are dysfunctional and unable to
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …
halt cancer progression. TST dysfunction, also known as exhaustion, is thought to be driven …
Current advances and challenges in CAR T-Cell therapy for solid tumors: tumor-associated antigens and the tumor microenvironment
T Yan, L Zhu, J Chen - Experimental Hematology & Oncology, 2023 - Springer
The past decade has witnessed ongoing progress in immune therapy to ameliorate human
health. As an emerging technique, chimeric antigen receptor (CAR) T-cell therapy has the …
health. As an emerging technique, chimeric antigen receptor (CAR) T-cell therapy has the …
Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens
Clinical response to adoptive T cell therapies is associated with the transcriptional and
epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and …
epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and …
Stem-like exhausted and memory CD8+ T cells in cancer
T Gebhardt, SL Park, IA Parish - Nature Reviews Cancer, 2023 - nature.com
T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
Enhanced T cell effector activity by targeting the Mediator kinase module
T cells are the major arm of the immune system responsible for controlling and regressing
cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR …
cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR …
Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells
Chimeric antigen receptor (CAR) T cell therapy has limited efficacy against solid tumors, and
one major challenge is T cell exhaustion. To address this challenge, we performed a …
one major challenge is T cell exhaustion. To address this challenge, we performed a …
Base-editing mutagenesis maps alleles to tune human T cell functions
CRISPR-enabled screening is a powerful tool for the discovery of genes that control T cell
function and has nominated candidate targets for immunotherapies,,,,–. However, new …
function and has nominated candidate targets for immunotherapies,,,,–. However, new …