Thirty years ago, De Bold et al. reported that atrial extracts contain some biologically active
peptides, which promote a rapid and massive diuresis and natriuresis when injected in rats …

The discovery of cardiac natriuretic hormones required a profound revision of the concept of
heart function. The heart should no longer be considered only as a pump but rather as a …

Objectives: These studies describe molecular forms of circulating B-type natriuretic peptide
(BNP) as well as their biological activity. Background: Increased circulating levels of …

C-terminal brain (B-type) natriuretic peptide (BNP)-32 is a widely used clinical biomarker for
the diagnosis, prognosis, and treatment of heart failure (HF). The 32-aa peptide is …

The aim of this review is to analyze in detail some possible pathophysiological mechanisms
linking obesity and cardiac endocrine function, in order to try to explain the negative …

Background—The myocardium secretes B-type natriuretic peptide (BNP) in response to
stimuli associated with heart failure (HF). However, high immunoreactive-BNP levels in …

Background: Analysis of plasma B-type natriuretic peptide (BNP) has suggested the in vivo
formation of a truncated form, BNP (3–32), also called des-SerPro-BNP. The objectives of …

Human pro-B-type natriuretic peptide (proBNP), the precursor for B-type natriuretic peptide
(BNP), was expressed in Chinese hamster ovary cells (CHO) and compared by Western blot …

Background: Processing of the brain natriuretic peptide (BNP) precursor, proBNP, is a
convertase-dependent reaction that produces 2 molecules—the active BNP hormone and …

BNP as a biomarker in heart disease Page 17 ADVANCES IN CLINICAL CHEMISTRY, VOL.
40 BNP AS A BIOMARKER IN HEART DISEASE Olli Vuolteenaho,* Minna Ala Kopsala,* and …