[PDF][PDF] 15 years of GWAS discovery: realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
Candidate biomarkers in psychiatric disorders: state of the field
The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …
aid in objectively diagnosing patients and providing individualized treatment …
Psychiatric diagnosis and treatment in the 21st century: paradigm shifts versus incremental integration
Psychiatry has always been characterized by a range of different models of and approaches
to mental disorder, which have sometimes brought progress in clinical practice, but have …
to mental disorder, which have sometimes brought progress in clinical practice, but have …
Explainable artificial intelligence for mental health through transparency and interpretability for understandability
The literature on artificial intelligence (AI) or machine learning (ML) in mental health and
psychiatry lacks consensus on what “explainability” means. In the more general XAI …
psychiatry lacks consensus on what “explainability” means. In the more general XAI …
New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …
Genetics and neurobiology of eating disorders
Eating disorders (anorexia nervosa, bulimia nervosa and binge-eating disorder) are a
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …
heterogeneous class of complex illnesses marked by weight and appetite dysregulation …
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohorts
Abstract Background Polygenic scores (PGSs), which assess the genetic risk of individuals
for a disease, are calculated as a weighted count of risk alleles identified in genome-wide …
for a disease, are calculated as a weighted count of risk alleles identified in genome-wide …
Genetic patterning for child psychopathology is distinct from that for adults and implicates fetal cerebellar development
Childhood psychiatric symptoms are often diffuse but can coalesce into discrete mental
illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic …
illnesses during late adolescence. We leveraged polygenic scores (PGSs) to parse genomic …
Improved genetic prediction of complex traits from individual-level data or summary statistics
Most existing tools for constructing genetic prediction models begin with the assumption that
all genetic variants contribute equally towards the phenotype. However, this represents a …
all genetic variants contribute equally towards the phenotype. However, this represents a …
Genetics of obsessive-compulsive disorder
BackgroundObsessive-compulsive disorder (OCD) is a psychiatric disorder with multiple
symptom dimensions (eg contamination, symmetry). OCD clusters in families and decades …
symptom dimensions (eg contamination, symmetry). OCD clusters in families and decades …