Inflammasomes in neurological disorders—mechanisms and therapeutic potential

KA Ravichandran, MT Heneka - Nature Reviews Neurology, 2024 - nature.com
Inflammasomes are molecular scaffolds that are activated by damage-associated and
pathogen-associated molecular patterns and form a key element of innate immune …

Caspase cleavage of gasdermin E causes neuronal pyroptosis in HIV-associated neurocognitive disorder

JP Fernandes, WG Branton, EA Cohen, G Koopman… - Brain, 2024 - academic.oup.com
Abstract Despite effective antiretroviral therapies, 20–30% of persons with treated HIV
infection develop a neurodegenerative syndrome termed HIV-associated neurocognitive …

Severe acute respiratory syndrome coronavirus 2 infection leads to Tau pathological signature in neurons

C Di Primio, P Quaranta, M Mignanelli, G Siano… - PNAS …, 2023 - academic.oup.com
COVID-19 has represented an issue for global health since its outbreak in March 2020. It is
now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Characterizing long-COVID brain fog: A retrospective cohort study

GY Lam, RW Damant, G Ferrara, RK Lim… - Journal of …, 2023 - Springer
Background Long COVID or post-COVID condition (PCC) is a common complication
following acute COVID-19 infection. PCC is a multi-systems disease with neurocognitive …

Cerebrospinal fluid metabolomic and proteomic characterization of neurologic post-acute sequelae of SARS-CoV-2 infection

S Chen, J Liang, D Chen, Q Huang, K Sun… - Brain, Behavior, and …, 2024 - Elsevier
The mechanism by which SARS-CoV-2 causes neurological post-acute sequelae of SARS-
CoV-2 (neuro-PASC) remains unclear. Herein, we conducted proteomic and metabolomic …

[HTML][HTML] Microfluidic Isolation of Neuronal-Enriched Extracellular Vesicles Shows Distinct and Common Neurological Proteins in Long COVID, HIV Infection and …

L Pulliam, B Sun, E McCafferty, SA Soper… - International Journal of …, 2024 - mdpi.com
Long COVID (LongC) is associated with a myriad of symptoms including cognitive
impairment. We reported at the beginning of the COVID-19 pandemic that neuronal …

Current clinical findings of acute neurological syndromes after SARS‐CoV‐2 infection

M Wang, J Wang, Y Ren, L Lu, W Xiong, L Li, S Xu… - MedComm, 2024 - Wiley Online Library
Neuro‐COVID, a condition marked by persistent symptoms post‐COVID‐19 infection,
notably affects various organs, with a particular focus on the central nervous system (CNS) …

[HTML][HTML] The Wnt/β-catenin pathway is important for replication of SARS-CoV-2 and other pathogenic RNA viruses

Z Xu, M Elaish, CP Wong, BB Hassan, J Lopez-Orozco… - npj Viruses, 2024 - nature.com
Understanding how viruses affect cellular pathways during infection may facilitate
development of host cell-targeted therapeutics with broad-spectrum antiviral activity. The …

[HTML][HTML] Discovering common pathogenetic processes between tuberculosis and COVID-19 by bioinformatics and system biology approach

X Liu, H Li, Y Wang, S Li, W Ren, J Yuan, Y Pang - Heliyon, 2024 - cell.com
Abstract Background SARS-CoV-2, the cause of the COVID-19 pandemic, poses a
significant threat to humanity. Individuals with pulmonary tuberculosis (PTB) are at increased …

[HTML][HTML] Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine model

VD Krishna, A Chang, H Korthas, SR Var, WC Low, L Li… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Abstract Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological
agent for the worldwide COVID-19 pandemic, is known to infect people of all ages and both …