Antibodies play an essential role in host defence against pathogens by recognizing
microorganisms or infected cells. Although preventing pathogen entry is one potential …

Immunoglobulins are unique molecules capable of simultaneously recognizing a diverse
array of antigens and themselves being recognized by a broad array of receptors. The …

Excessive production of aldosterone leads to the development of hypertension and
cardiovascular disease by generating an inflammatory state that can be promoted by T cell …

Professional phagocytosis in mammals is considered to be performed exclusively by
myeloid cell types. In this study, we demonstrate, for the first time, that a mammalian …

Salmonella enterica is a frequent gastrointestinal pathogen with ability to cause diseases
ranging from local gastrointestinal inflammation and diarrhea to life‐threatening typhoid …

Dendritic cells (DCs) are responsible for priming T-cells and for promoting their
differentiation from naïve T-cells into appropriate effector cells. Because of their fundamental …

For years, clusterin has been recognized as a secreted protein and a large number of works
demonstrated that this ubiquitously expressed protein has multiple activities. Among the …

FcγRIIb is the only inhibitory Fc receptor and controls many aspects of immune and
inflammatory responses. The observation 19 years ago that Fc γ RIIb−/− mice generated by …

Dendritic cells (DCs) play a key role in the activation of the immune response against
pathogens, as well as in the modulation of peripheral tolerance to self-antigens (Ags) …

The protective effect of antibodies (Abs) is generally attributed to neutralization or
complement activation. Using Legionella pneumophila and Mycobacterium bovis bacillus …