The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
Nanobodies: robust miniprotein binders in biomedicine
Variable domains of heavy chain-only antibodies (VHH), also known as nanobodies (Nbs),
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
are monomeric antigen-binding domains derived from the camelid heavy chain-only …
Phage-Displayed Nanobody as a Sensitive Nanoprobe to Enhance Chemiluminescent Immunoassay for Cronobacter sakazakii Detection in Dairy Products
Y Zhang, X Liao, G Yu, J Wei, P Wang… - Analytical …, 2023 - ACS Publications
The exploitation of stable, high-affinity, and low-cost nanoprobes is essential to develop
immunoassays for real-time monitoring of foodborne pathogens, so as to safeguard human …
immunoassays for real-time monitoring of foodborne pathogens, so as to safeguard human …
Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster models
Nanobodies offer several potential advantages over mAbs for the control of SARS-CoV-2.
Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern …
Their ability to access cryptic epitopes conserved across SARS-CoV-2 variants of concern …
The potential of nanobodies for COVID-19 diagnostics and therapeutics
DB Naidoo, AA Chuturgoon - Molecular Diagnosis & Therapy, 2023 - Springer
The infectious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the
causative agent for coronavirus disease 2019 (COVID-19). Globally, there have been …
causative agent for coronavirus disease 2019 (COVID-19). Globally, there have been …
[HTML][HTML] Bovine-derived antibodies and camelid-derived nanobodies as biotherapeutic weapons against SARS-CoV-2 and its variants: a review article
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected 305 million individuals …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected 305 million individuals …
Emerging landscape of nanobodies and their neutralizing applications against SARS-CoV-2 virus
X Feng, H Wang - ACS Pharmacology & Translational Science, 2023 - ACS Publications
The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes the
coronavirus disease 2019 (COVID-19) has significantly altered people's way of life. Despite …
coronavirus disease 2019 (COVID-19) has significantly altered people's way of life. Despite …
Studying the characteristics of nanobody CDR regions based on sequence analysis in combination with 3D structures
Background Single-domain antibodies or nanobodies have recently attracted much attention
in research and applications because of their great potential and advantage over …
in research and applications because of their great potential and advantage over …
Next generation single-domain antibodies against respiratory zoonotic RNA viruses
IC Swart, W Van Gelder, CAM De Haan… - Frontiers in Molecular …, 2024 - frontiersin.org
The global impact of zoonotic viral outbreaks underscores the pressing need for innovative
antiviral strategies, particularly against respiratory zoonotic RNA viruses. These viruses …
antiviral strategies, particularly against respiratory zoonotic RNA viruses. These viruses …
A potent alpaca-derived nanobody that neutralizes SARS-CoV-2 variants
The spike glycoprotein of SARS-CoV-2 engages with human ACE 2 to facilitate infection.
Here, we describe an alpaca-derived heavy chain antibody fragment (VHH), saRBD-1, that …
Here, we describe an alpaca-derived heavy chain antibody fragment (VHH), saRBD-1, that …