Senescence is linked to a wide range of age-associated diseases and physiological
declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of …

Anti-tumorigenic mechanisms mediated by the tumor suppressor p53, upon oncogenic
stresses, are our bodies' greatest weapons to battle against cancer onset and development …

Activation of the p53 tumor suppressor triggers a transcriptional program to control cellular
response to stress. However, the molecular mechanisms by which p53 controls gene …

DNA methyltransferase inhibitors (DNMTis) reexpress hypermethylated genes in cancers
and leukemias and also activate endogenous retroviruses (ERVs), leading to interferon …

The gene TP53, which encodes the tumor suppressor protein p53, is mutated in about 50%
of cancers. In response to cell stressors like DNA damage and after treatment with DNA …

Simple Summary p53 is best known for its tumour suppressive functions mediated through
regulation of an extensive-gene regulatory network. Here we review progress in our …

Ageing is characterised by a physical decline in biological functioning which results in a
progressive risk of mortality with time. As a biological phenomenon, it is underpinned by the …

p53 plays a central role in defending the genomic integrity of our cells. In response to
genotoxic stress, this tumour suppressor orchestrates the expression of hundreds of target …

Keratin 17 (K17) is a cytoskeletal protein that is part of the intermediate filaments in
epidermal keratinocytes. In K17−/− mice, ionizing radiation induced more severe hair follicle …

Cell stress and DNA damage activate the tumor suppressor p53, triggering transcriptional
activation of a myriad of target genes. The molecular, morphological, and physiological …