Heat shock proteins (HSPs) are constitutively expressed under physiological conditions in
most organisms but their expression can significantly enhance in response to four types of …

Viruses are intracellular pathogens responsible for a vast number of human diseases. Due
to their small genome size, viruses rely primarily on the biosynthetic apparatus of the host for …

Hsp90ab1 is upregulated in numerous solid tumors, which is thought to induce the
angiogenesis and promote cancer metastasis. However, it's actions in gastric cancer (GC) …

The emergence of antiviral drug-resistant mutants is the most important issue in current
antiviral therapy. As obligate parasites, viruses require host factors for efficient replication …

Colon cancer, a common type of malignant tumor, seriously endangers human health.
However, due to the relatively slow progress in diagnosis and treatment, the clinical …

Heat shock protein 90 (HSP90) family of proteins are ubiquitous molecular chaperones that
are involved in folding, activation, maturation and assembly of many proteins that include …

Viruses have been shown to be responsible for 10%-15% of cancer cases. Epstein-Barr
virus (EBV) is the first virus to be associated with human malignancies. EBV can cause many …

T-cell malignancies, mainly known as T-cell acute lymphoblastic leukemia (T-ALL) and T-
cell non-Hodgkin's lymphoma (T-NHL), are aggressive tumors. Although the clinical …

PU-H71 is a purine-scaffold Hsp90 inhibitor that, in contrast to other Hsp90 inhibitors,
displays unique selectivity for binding the fraction of Hsp90 that is preferentially associated …

Misfolded proteins after stress-induced denaturation can regain their functions through
correct re-folding with the aid of molecular chaperones. As a molecular chaperone, heat …