Mediator was discovered because of its activity in a yeast RNA polymerase II (pol II)
transcription system–it is needed for the system to respond to a transcriptional activator …

This review focuses on the gene-enzyme relationships and the regulation of different levels
of the aromatic amino acid biosynthetic pathway in a simple eukaryotic system, the …

One gene activator protein may interfere with the effects of another in eukaryotic cells. We
report here that a hybrid yeast-herpes gene activator pmtein inhibits transcriptional …

ACTIVATOR proteins bind to enhancer DNA elements and stimu-late the initiation of
transcription. It has been proposed1–3 that activators contact general initiation factors at a …

▪ Abstract Three lines of evidence have converged on a multiprotein Mediator complex as a
conserved interface between gene-specific regulatory proteins and the general transcription …

A family of protein kinases regulates translation in response to different cellular stresses by
phosphorylation of the α subunit of eukaryotic initiation factor-2 (eIF-2α). In yeast, an eIF-2α …

Virion protein 16 (VP16) of herpes simplex virus type 1 contains an acidic transcriptional
activation domain. Missense mutations within this domain have provided insights into the …

The X-ray structure of the DNA binding domain of the yeast transcriptional activator protein
GCN4 bound to a DNA fragment containing the sequence of the perfectly symmetrical …

Two principal models have been invoked to explain transcriptional stimulation of RNA
polymerase II genes by enhancers/upstream promoter elements: in one, upstream …

Most eukaryotic promoter regions are divergently transcribed. As the RNA polymerase II pre-
initiation complex (PIC) is intrinsically asymmetric and responsible for transcription in a …