Dry Powder Inhaler with the technical and practical obstacles, and forthcoming platform strategies

SS Gaikwad, SR Pathare, MA More… - Journal of Controlled …, 2023 - Elsevier
Abstract A Dry Powder Inhaler (DPI) is a technique as well as a device used to inhale
formulation which is in the form of dry powder, and is inhaled through the nose or mouth. It …

A comprehensive overview of dry powder inhalers for pulmonary drug delivery: Challenges, advances, optimization techniques, and applications

HI Shahin, L Chablani - Journal of Drug Delivery Science and Technology, 2023 - Elsevier
Dry powder inhaler (DPI) is an attractive dosage form for local and systemic pulmonary drug
delivery. However, designing DPIs with adequate physicochemical properties is …

An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models

E Urano, Y Itoh, T Suzuki, T Sasaki… - Science translational …, 2023 - science.org
The Omicron variant continuously evolves under the humoral immune pressure exerted by
vaccination and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Ranking the risks of eighty pharmaceuticals in surface water of a megacity: A multilevel optimization strategy

M Chen, Y Hong, X Jin, C Guo, X Zhao, N Liu… - Science of the Total …, 2023 - Elsevier
Pharmaceuticals in freshwater posed ecological risks to aquatic ecosystem, however, most
risk assessments of pharmaceuticals were conducted at screening level, which were limited …

Inhalation of vaccines and antiviral drugs to fight respiratory virus infections: reasons to prioritize the pulmonary route of administration

R Heida, HW Frijlink, WLJ Hinrichs - Mbio, 2023 - Am Soc Microbiol
Many of the current pandemic threats are caused by viruses that infect the respiratory tract.
Remarkably though, the majority of vaccines and antiviral drugs are administered via …

Treatment of respiratory viral infections through inhalation therapeutics: Challenges and opportunities

N Nainwal - Pulmonary Pharmacology & Therapeutics, 2022 - Elsevier
Respiratory viral infections are the leading cause of death worldwide. The current pandemic
of coronavirus infection (COVID-19) challenged human beings for the treatment and …

Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time …

A Yildiz Pekoz, O Akbal Dagistan, H Fael, M Culha… - Drug Delivery, 2022 - Taylor & Francis
Favipiravir, an RNA-dependent RNA polymerase (RdRp) inhibitor, is used to treat patients
infected with influenza virus and most recently with SARS-CoV-2. However, poor …

Potential of green tea EGCG in neutralizing SARS-CoV-2 Omicron variant with greater tropism toward the upper respiratory tract

Z Zhang, M Hao, X Zhang, Y He, X Chen… - Trends in Food Science …, 2023 - Elsevier
Background COVID-19 due to SARS-CoV-2 infection has had an enormous adverse impact
on global public health. As the COVID-19 pandemic evolves, the WHO declared several …

Dopamine and its precursor levodopa inactivate SARS-CoV-2 main protease by forming a quinoprotein

M Hao, Y He, T Song, H Guo, MP Rayman… - Free Radical Biology and …, 2024 - Elsevier
Many studies show either the absence, or very low levels of, SARS-CoV-2 viral RNA and/or
antigen in the brain of COVID-19 patients. Reports consistently indicate an abortive infection …

Strictinin, a major ingredient in Yunnan kucha tea possessing inhibitory activity on the infection of mouse hepatitis virus to mouse L cells

EC Tu, WL Hsu, JTC Tzen - Molecules, 2023 - mdpi.com
Theacrine and strictinin of Yunnan Kucha tea prepared from a mutant variety of wild Pu'er
tea plants were two major ingredients responsible for the anti-influenza activity. As the …