Recent clinical trends in Toll‐like receptor targeting therapeutics
Toll‐like receptors (TLRs) are germline‐encoded receptors that are central to innate and
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …
adaptive immune responses. Owing to their vital role in inflammation, TLRs are rational …
The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent need for …
Many randomized controlled trials (RCTs) are biased and difficult to reproduce due to
methodological flaws and poor reporting. There is increasing attention for responsible …
methodological flaws and poor reporting. There is increasing attention for responsible …
Assessing scientists for hiring, promotion, and tenure
Assessment of researchers is necessary for decisions of hiring, promotion, and tenure. A
burgeoning number of scientific leaders believe the current system of faculty incentives and …
burgeoning number of scientific leaders believe the current system of faculty incentives and …
Clinical trial design and dissemination: comprehensive analysis of clinicaltrials. gov and PubMed data since 2005
M Zwierzyna, M Davies, AD Hingorani, J Hunter - Bmj, 2018 - bmj.com
Objective To investigate the distribution, design characteristics, and dissemination of clinical
trials by funding organisation and medical specialty. Design Cross sectional descriptive …
trials by funding organisation and medical specialty. Design Cross sectional descriptive …
Early discontinuation, results reporting, and publication of pediatric clinical trials
METHODS Cross-sectional analysis of clinical trials enrolling participants< 18 years old
registered at ClinicalTrials. gov from October 2007 to March 2020. Multivariable logistic …
registered at ClinicalTrials. gov from October 2007 to March 2020. Multivariable logistic …
Big data in drug discovery
Abstract Interpretation of Big Data in the drug discovery community should enhance project
timelines and reduce clinical attrition through improved early decision making. The issues …
timelines and reduce clinical attrition through improved early decision making. The issues …
Result dissemination from clinical trials conducted at German university medical centers was delayed and incomplete
S Wieschowski, N Riedel, K Wollmann… - Journal of Clinical …, 2019 - Elsevier
Objectives Timely and comprehensive reporting of clinical trial results builds the backbone
of evidence-based medicine and responsible research. The proportion of timely …
of evidence-based medicine and responsible research. The proportion of timely …
Pharmaceutical companies' policies on access to trial data, results, and methods: audit study
B Goldacre, S Lane, KR Mahtani, C Heneghan… - bmj, 2017 - bmj.com
Objectives To identify the policies of major pharmaceutical companies on transparency of
trials, to extract structured data detailing each companies' commitments, and to assess …
trials, to extract structured data detailing each companies' commitments, and to assess …
Evaluation of oncology trial results reporting over a 10-year period
Importance Unreported clinical trial results represent a violation of human rights. Oncology
trials account for nearly 30% of interventional biopharmaceutical clinical studies registered …
trials account for nearly 30% of interventional biopharmaceutical clinical studies registered …
Integrated deep learned transcriptomic and structure-based predictor of clinical trials outcomes
Despite many recent advances in systems biology and a marked increase in the availability
of high-throughput biological data, the productivity of research and development in the …
of high-throughput biological data, the productivity of research and development in the …