[HTML][HTML] Phylogenetic and phylodynamic approaches to understanding and combating the early SARS-CoV-2 pandemic
Determining the transmissibility, prevalence and patterns of movement of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is central to our understanding …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infections is central to our understanding …
[HTML][HTML] SARS-CoV-2 mutations and their impact on diagnostics, therapeutics and vaccines
S Thakur, S Sasi, SG Pillai, A Nag, D Shukla… - Frontiers in …, 2022 - frontiersin.org
With the high rate of COVID-19 infections worldwide, the emergence of SARS-CoV-2
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …
variants was inevitable. Several mutations have been identified in the SARS-CoV-2 …
[HTML][HTML] Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern
L Vangeel, W Chiu, S De Jonghe, P Maes, B Slechten… - Antiviral research, 2022 - Elsevier
We assessed the in vitro antiviral activity of remdesivir and its parent nucleoside GS-441524,
molnupiravir and its parent nucleoside EIDD-1931 and the viral protease inhibitor …
molnupiravir and its parent nucleoside EIDD-1931 and the viral protease inhibitor …
[HTML][HTML] TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
J Baggen, M Jacquemyn, L Persoons, E Vanstreels… - Cell, 2023 - cell.com
SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …
[HTML][HTML] Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape
Z Zhao, J Zhou, M Tian, M Huang, S Liu, Y Xie… - Nature …, 2022 - nature.com
Omicron SARS-CoV-2 is rapidly spreading worldwide. To delineate the impact of emerging
mutations on spike's properties, we performed systematic structural analyses on apo …
mutations on spike's properties, we performed systematic structural analyses on apo …
SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex
D Mannar, JW Saville, X Zhu, SS Srivastava… - Science, 2022 - science.org
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo …
Recent developments in the immunopathology of COVID‐19
There has been an important change in the clinical characteristics and immune profile of
Coronavirus disease 2019 (COVID‐19) patients during the pandemic thanks to the …
Coronavirus disease 2019 (COVID‐19) patients during the pandemic thanks to the …
[HTML][HTML] A detailed overview of immune escape, antibody escape, partial vaccine escape of SARS-CoV-2 and their emerging variants with escape mutations
The infective SARS-CoV-2 is more prone to immune escape. Presently, the significant
variants of SARS-CoV-2 are emerging in due course of time with substantial mutations …
variants of SARS-CoV-2 are emerging in due course of time with substantial mutations …
[HTML][HTML] Molecular characteristics, immune evasion, and impact of SARS-CoV-2 variants
The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …
burden to the global society and is accompanied by various evolution of the virus genome …
Differential interactions between human ACE2 and spike RBD of SARS-CoV-2 variants of concern
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the current coronavirus disease 2019 (COVID-19) pandemic. It is known that the receptor …
the current coronavirus disease 2019 (COVID-19) pandemic. It is known that the receptor …