Role of macrophages in the progression and regression of vascular calcification

Y Li, Z Sun, L Zhang, J Yan, C Shao, L Jing… - Frontiers in …, 2020 - frontiersin.org
Vascular calcification is an abnormal cell-mediated process in which bone-specific
hydroxyapatite crystals are actively deposited on the blood vessel wall and is a significant …

The bone-vessel axis in chronic kidney disease: An update on biochemical players and its future role in laboratory medicine

L Pereira, JM Frazão - Clinica Chimica Acta, 2020 - Elsevier
Vascular wall calcification (VC) is highly prevalent in patients with chronic kidney disease
(CKD). In CKD, VC is more frequent and severe than in the general population and it is …

[HTML][HTML] Oxidative stress contributes to vascular calcification in patients with chronic kidney disease

M Huang, L Zheng, H Xu, D Tang, L Lin, J Zhang… - Journal of Molecular and …, 2020 - Elsevier
Vascular calcification (VC) is a major cause of mortality in patients with chronic kidney
disease (CKD). While elevations in serum phosphorus contribute to VC, we provide …

Oxidative stress by Ca2+ overload is critical for phosphate-induced vascular calcification

NT Nguyen, TT Nguyen, D Da Ly… - American Journal …, 2020 - journals.physiology.org
Hyperphosphatemia is the primary risk factor for vascular calcification, which is closely
associated with cardiovascular morbidity and mortality. Recent evidence showed that …

[HTML][HTML] Microvesicles from indoxyl sulfate-treated endothelial cells induce vascular calcification in vitro

M Alique, G Bodega, E Corchete… - Computational and …, 2020 - Elsevier
Vascular calcification (VC), an unpredictable pathophysiological process and critical event
in patients with cardiovascular diseases (CVDs), is the leading cause of morbi-mortality and …

The Crosstalk between Calcium Ions and Aldosterone Contributes to Inflammation, Apoptosis, and Calcification of VSMC via the AIF‐1/NF‐κB Pathway in Uremia

J Hao, J Tang, L Zhang, X Li… - Oxidative Medicine and …, 2020 - Wiley Online Library
Vascular calcification is a major complication of maintenance hemodialysis patients. Studies
have confirmed that calcification mainly occurs in the vascular smooth muscle cells (VSMC) …

Implications of senescent cell burden and NRF2 pathway in uremic calcification: a translational study

J Laget, S Hobson, K Muyor, F Duranton, I Cortijo… - Cells, 2023 - mdpi.com
Increased senescent cell burden and dysregulation of the nuclear factor erythroid 2–related
factor 2 (NRF2) pathway have been associated with numerous age-related pathologies; …

Magnesium to prevent kidney disease–associated vascular calcification: crystal clear?

AD Ter Braake, MG Vervloet… - Nephrology Dialysis …, 2022 - academic.oup.com
Vascular calcification is a prognostic marker for cardiovascular mortality in chronic kidney
disease (CKD) patients. In these patients, magnesium balance is disturbed, mainly due to …

Salt-Sensitive Hypertension: Mediation by Salt-Induced Hypervolemia and Phosphate-Induced Vascular Calcification

RB Brown - Clinical Medicine Insights: Cardiology, 2023 - journals.sagepub.com
Preventing hypertension by restricting dietary salt intake, sodium chloride, is well
established in public health policy, but a pathophysiological mechanism has yet to explain …

OGT knockdown counteracts high phosphate-induced vascular calcification in chronic kidney disease through autophagy activation by downregulating YAP

TH Xu, Z Sheng, Y Li, X Qiu, B Tian, L Yao - Life sciences, 2020 - Elsevier
Aims Pathological vascular calcification (VC), a major risk factor for cardiovascular mortality,
is a highly prevalent finding in patients with chronic kidney disease (CKD). We previously …