Unconventional peptide presentation by major histocompatibility complex (MHC) class I allele HLA-A* 02: 01: BREAKING CONFINEMENT

SG Remesh, M Andreatta, G Ying, T Kaever… - Journal of Biological …, 2017 - ASBMB
Peptide antigen presentation by major histocompatibility complex (MHC) class I proteins
initiates CD8+ T cell-mediated immunity against pathogens and cancers. MHC I molecules …

Poorly cytotoxic terminally differentiated CD56negCD16pos NK cells accumulate in Kenyan children with Burkitt lymphomas

CS Forconi, CP Cosgrove… - Blood …, 2018 - ashpublications.org
Natural killer (NK) cells are critical for restricting viral infections and mediating tumor
immunosurveillance. Epstein-Barr virus (EBV) and Plasmodium falciparum malaria are …

Natural killer cells as a promising therapeutic target for cancer immunotherapy

N Kim, HH Lee, HJ Lee, WS Choi, J Lee… - Archives of pharmacal …, 2019 - Springer
Natural killer (NK) cells are innate lymphoid cells that provide early protection against
cancer development via their selectivity to kill abnormal cells undergoing cellular …

Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells

WH Palmer, LA Leaton, A Campos Codo, B Crute… - Science …, 2023 - science.org
Most human killer cell immunoglobulin-like receptors (KIR) are expressed by natural killer
(NK) cells and recognize HLA class I molecules as ligands. KIR3DL3 is a conserved but …

Two to tango: co-evolution of hominid natural killer cell receptors and MHC

EE Wroblewski, P Parham, LA Guethlein - Frontiers in immunology, 2019 - frontiersin.org
Natural killer (NK) cells have diverse roles in hominid immunity and reproduction.
Modulating these functions are the interactions between major histocompatibility complex …

Natural killer cell receptors regulate responses of HLA-E–restricted T cells

LC Sullivan, THO Nguyen, CM Harpur… - Science …, 2021 - science.org
Human cytomegalovirus (CMV) infection can stimulate robust human leukocyte antigen
(HLA)–E–restricted CD8+ T cell responses. These T cells recognize a peptide from UL40 …

Analysis of Genomic DNA from Medieval Plague Victims Suggests Long-Term Effect of Yersinia pestis on Human Immunity Genes

A Immel, FM Key, A Szolek, R Barquera… - Molecular biology …, 2021 - academic.oup.com
Pathogens and associated outbreaks of infectious disease exert selective pressure on
human populations, and any changes in allele frequencies that result may be especially …

Open MHC class I conformers: A look through the looking glass

FA Arosa, AJ Esgalhado, D Reste-Ferreira… - International journal of …, 2021 - mdpi.com
Studies carried out during the last few decades have consistently shown that cell surface
MHC class I (MHC-I) molecules are endowed with functions unrelated with antigen …

An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell …

VA Vieira, E Adland, DFG Malone, MP Martin… - PLoS …, 2021 - journals.plos.org
Natural Killer (NK) cells contribute to HIV control in adults, but HLA-B-mediated T-cell activity
has a more substantial impact on disease outcome. However, the HLA-B molecules …

Adaptive admixture of HLA class I allotypes enhanced genetically determined strength of natural killer cells in East Asians

Z Deng, J Zhen, GF Harrison, G Zhang… - Molecular biology …, 2021 - academic.oup.com
Human natural killer (NK) cells are essential for controlling infection, cancer, and fetal
development. NK cell functions are modulated by interactions between polymorphic …