[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
Combining SNP-to-gene linking strategies to identify disease genes and assess disease omnigenicity
Disease-associated single-nucleotide polymorphisms (SNPs) generally do not implicate
target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking …
target genes, as most disease SNPs are regulatory. Many SNP-to-gene (S2G) linking …
Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data
Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …
[HTML][HTML] Redefining the hypotheses driving Parkinson's diseases research
SL Farrow, AA Cooper, JM O'Sullivan - NPJ Parkinson's disease, 2022 - nature.com
Parkinson's disease (PD) research has largely focused on the disease as a single entity
centred on the development of neuronal pathology within the central nervous system …
centred on the development of neuronal pathology within the central nervous system …
[HTML][HTML] Repression and 3D-restructuring resolves regulatory conflicts in evolutionarily rearranged genomes
AR Ringel, Q Szabo, AM Chiariello, K Chudzik… - Cell, 2022 - cell.com
Regulatory landscapes drive complex developmental gene expression, but it remains
unclear how their integrity is maintained when incorporating novel genes and functions …
unclear how their integrity is maintained when incorporating novel genes and functions …
[HTML][HTML] Exploring the genetic basis of coronary artery disease using functional genomics
ML Rodríguez, UT Arasu, MU Kaikkonen - Atherosclerosis, 2023 - Elsevier
Abstract Genome-wide Association Studies (GWAS) have identified more than 300 loci
associated with coronary artery disease (CAD), defining the genetic risk map of the disease …
associated with coronary artery disease (CAD), defining the genetic risk map of the disease …
[HTML][HTML] Mapping cis-regulatory elements in human neurons links psychiatric disease heritability and activity-regulated transcriptional programs
Genome-wide association studies (GWASs) have identified hundreds of loci associated with
psychiatric diseases, yet there is a lack of understanding of disease pathophysiology …
psychiatric diseases, yet there is a lack of understanding of disease pathophysiology …
Computational model for disease research
Computational analysis of vast public and private omics data [1–5] generated by high-
throughput technologies [6, 7] aids in deciphering complex mechanisms [8–11] and relevant …
throughput technologies [6, 7] aids in deciphering complex mechanisms [8–11] and relevant …
[HTML][HTML] Integrating genetic regulation and single-cell expression with GWAS prioritizes causal genes and cell types for glaucoma
AR Hamel, W Yan, JM Rouhana… - Nature …, 2024 - nature.com
Primary open-angle glaucoma (POAG), characterized by retinal ganglion cell death, is a
leading cause of irreversible blindness worldwide. However, its molecular and cellular …
leading cause of irreversible blindness worldwide. However, its molecular and cellular …