Natural coumarins: exploring the pharmacological complexity and underlying molecular mechanisms

J Sharifi-Rad, N Cruz-Martins… - Oxidative Medicine …, 2021 - Wiley Online Library
Coumarins belong to the benzopyrone family commonly found in many medicinal plants.
Natural coumarins demonstrated a wide spectrum of pharmacological activities, including …

Skin whitening agents: Medicinal chemistry perspective of tyrosinase inhibitors

T Pillaiyar, M Manickam… - Journal of enzyme …, 2017 - Taylor & Francis
Melanogenesis is a process to synthesize melanin, which is a primary responsible for the
pigmentation of human skin, eye and hair. Although numerous enzymatic catalyzed and …

Synthesis and application of coumarin fluorescence probes

X Sun, T Liu, J Sun, X Wang - RSC advances, 2020 - pubs.rsc.org
In recent years, the research on fluorescent probes has developed rapidly. Coumarin
fluorescent probes have also been one of the hot topics in recent years. For the synthesis …

Current developments of coumarin compounds in medicinal chemistry

XM Peng, G LV Damu, H Zhou - Current pharmaceutical …, 2013 - ingentaconnect.com
Coumarin compounds represent an important type of naturally occurring and synthetic
oxygen-containing heterocycles with typical benzopyrone framework. This type of special …

Coumarins—an important class of phytochemicals

MJ Matos, L Santana, E Uriarte, OA Abreu… - … and role in human …, 2015 - books.google.com
Phytochemicals are chemical compounds that occur naturally in the plant kingdom. Some
are responsible for the organoleptic properties of the natural sources in which they are …

Coumarin hybrids as novel therapeutic agents

S Sandhu, Y Bansal, O Silakari, G Bansal - Bioorganic & medicinal …, 2014 - Elsevier
Naturally occurring coumarins, having wide spectrum of activities such as antioxidant, anti-
inflammatory, anticancer, MAO-B inhibitory and antimicrobial, are frequently used by the …

Radical C–H functionalization to construct heterocyclic compounds

JT Yu, C Pan - Chemical Communications, 2016 - pubs.rsc.org
Heterocyclic compounds are widely present in natural products, pharmaceuticals and
bioactive molecules. Thus, organic and pharmaceutical chemists have been making …

Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors

MJ Matos, C Teran, Y Perez-Castillo… - Journal of medicinal …, 2011 - ACS Publications
New series of 6-substituted-3-arylcoumarins displaying several alkyl, hydroxyl, halogen, and
alkoxy groups in the two benzene rings have been designed, synthesized, and evaluated in …

Preparation of 3-acyl-4-arylcoumarins via metal-free tandem oxidative acylation/cyclization between alkynoates with aldehydes

X Mi, C Wang, M Huang, Y Wu… - The Journal of Organic …, 2015 - ACS Publications
A new and efficient metal-free tandem acylation/cyclization of alkynoates with aldehydes
was developed for the synthesis of 3-acyl-4-arylcoumarins. The reaction was achieved by …

3-Substituted coumarins as dual inhibitors of AChE and MAO for the treatment of Alzheimer's disease

D Vina, MJ Matos, M Yáñez, L Santana, E Uriarte - MedChemComm, 2012 - pubs.rsc.org
The complex etiology of Alzheimer's disease (AD) has encouraged active research in the
development of multi-target drugs with two or more complementary biological activities …