ACE2/ADAM17/TMPRSS2 interplay may be the main risk factor for COVID-19

D Zipeto, JF Palmeira, GA Argañaraz… - Frontiers in …, 2020 - frontiersin.org
The Coronavirus Disease 2019 (COVID-19) has already caused hundreds of thousands of
deaths worldwide in a few months. Cardiovascular disease, hypertension, diabetes and …

[HTML][HTML] Current and future therapeutic perspective in chronic heart failure

A Mascolo, G Di Mauro, D Cappetta… - Pharmacological …, 2022 - Elsevier
The incidence of heart failure is primarily flat or declining for a presumably reflecting better
management of cardiovascular diseases, but that of heart failure with preserved ejection …

Immunological aspects of SARS-CoV-2 infection and the putative beneficial role of vitamin-D

MY Peng, WC Liu, JQ Zheng, CL Lu, YC Hou… - International journal of …, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) is still an ongoing global health crisis. Immediately after the …

Potential detrimental role of soluble ACE2 in severe COVID‐19 comorbid patients

MM Rahman, M Hasan, A Ahmed - Reviews in Medical Virology, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) enters the host cell by
binding to angiotensin‐converting enzyme 2 (ACE2) receptor. Other important proteins …

Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: The enigmatic entity

HM Al-Kuraishy, AI Al-Gareeb, YQ Almulaiky… - European journal of …, 2021 - Elsevier
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the responsible agent for
the coronavirus disease 2019 (Covid-19), has its entry point through interaction with …

SARS-CoV-2 spike protein S1-mediated endothelial injury and pro-inflammatory state is amplified by dihydrotestosterone and prevented by mineralocorticoid …

N Kumar, Y Zuo, S Yalavarthi, KL Hunker, JS Knight… - Viruses, 2021 - mdpi.com
Men are disproportionately affected by the coronavirus disease-2019 (COVID-19), and face
higher odds of severe illness and death compared to women. The vascular effects of …

The role of renin-angiotensin-aldosterone system in the heart and lung: focus on COVID-19

A Mascolo, C Scavone, C Rafaniello… - Frontiers in …, 2021 - frontiersin.org
The renin-angiotensin-aldosterone system (RAAS) firstly considered as a cardiovascular
circulating hormonal system, it is now accepted as a local tissue system that works …

Acute and chronic effects of COVID-19 on the cardiovascular system

V Arevalos, L Ortega-Paz, JJ Rodriguez-Arias… - Journal of …, 2021 - mdpi.com
COVID-19 has shown significant morbidity with the involvement of multiple systems,
including the cardiovascular system. Cardiovascular manifestations in the acute phase can …

Therapeutic strategies to fight COVID‐19: Which is the status artis?

C Scavone, A Mascolo, C Rafaniello… - British Journal of …, 2022 - Wiley Online Library
COVID‐19 is a complex disease, and many difficulties are faced today especially in the
proper choice of pharmacological treatments. The role of antiviral agents for COVID‐19 is …

Data-driven molecular design for discovery and synthesis of novel ligands: a case study on SARS-CoV-2

J Born, M Manica, J Cadow, G Markert… - Machine Learning …, 2021 - iopscience.iop.org
Bridging systems biology and drug design, we propose a deep learning framework for de
novo discovery of molecules tailored to bind with given protein targets. Our methodology is …