The SARS‐CoV‐2 main protease (Mpro): Structure, function, and emerging therapies for COVID‐19
Q Hu, Y Xiong, GH Zhu, YN Zhang, YW Zhang… - MedComm, 2022 - Wiley Online Library
The main proteases (Mpro), also termed 3‐chymotrypsin‐like proteases (3CLpro), are a
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …
class of highly conserved cysteine hydrolases in β‐coronaviruses. Increasing evidence has …
[HTML][HTML] Molecular modeling in drug discovery
TI Adelusi, AQK Oyedele, ID Boyenle… - Informatics in Medicine …, 2022 - Elsevier
With the financial requirements and high time associated with bringing a commercial drug to
the market, the application of computer-aided drug design has been recognized as a …
the market, the application of computer-aided drug design has been recognized as a …
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
[HTML][HTML] Peptide and peptide-based inhibitors of SARS-CoV-2 entry
To date, no effective vaccines or therapies are available against the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), the causative pandemic agent of the coronavirus …
syndrome coronavirus 2 (SARS-CoV-2), the causative pandemic agent of the coronavirus …
The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022
X Pang, W Xu, Y Liu, H Li, L Chen - European Journal of Medicinal …, 2023 - Elsevier
The novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The main protease (M pro) of …
syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. The main protease (M pro) of …
Perspectives on SARS-CoV-2 main protease inhibitors
The main protease (Mpro) plays a crucial role in severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …
coronavirus 2 (SARS-CoV-2) replication and is highly conserved, rendering it one of the …
Surface plasmon resonance aptasensor based on niobium carbide MXene quantum dots for nucleocapsid of SARS-CoV-2 detection
R Chen, L Kan, F Duan, L He, M Wang, J Cui, Z Zhang… - Microchimica Acta, 2021 - Springer
A novel label-free surface plasmon resonance (SPR) aptasensor has been constructed for
the detection of N-gene of SARS-CoV-2 by using thiol-modified niobium carbide MXene …
the detection of N-gene of SARS-CoV-2 by using thiol-modified niobium carbide MXene …
[HTML][HTML] A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19
The emergence of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected many countries throughout …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected many countries throughout …
Ultrafast one-minute electronic detection of SARS-CoV-2 infection by 3CLpro enzymatic activity in untreated saliva samples
E Borberg, E Granot, F Patolsky - Nature Communications, 2022 - nature.com
Since its onset in December 2019, severe acute respiratory syndrome coronavirus 2, SARS-
CoV-2, has caused over 6.5 million deaths worldwide as of October 2022. Attempts to curb …
CoV-2, has caused over 6.5 million deaths worldwide as of October 2022. Attempts to curb …
[HTML][HTML] Medicinal chemistry strategies towards the development of effective SARS-CoV-2 inhibitors
S Gao, T Huang, L Song, S Xu, Y Cheng… - … Pharmaceutica Sinica B, 2022 - Elsevier
Novel therapies are urgently needed to improve global treatment of SARS-CoV-2 infection.
Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the …
Herein, we briefly provide a concise report on the medicinal chemistry strategies towards the …