Polygenic scores in cancer
Since the publication of the first genome-wide association study for cancer in 2007,
thousands of common alleles that are associated with the risk of cancer have been …
thousands of common alleles that are associated with the risk of cancer have been …
Precision medicine in complex diseases—Molecular subgrouping for improved prediction and treatment stratification
Complex diseases are caused by a combination of genetic, lifestyle, and environmental
factors and comprise common noncommunicable diseases, including allergies …
factors and comprise common noncommunicable diseases, including allergies …
UK Biobank release and systematic evaluation of optimised polygenic risk scores for 53 diseases and quantitative traits
DJ Thompson, D Wells, S Selzam, I Peneva, R Moore… - MedRxiv, 2022 - medrxiv.org
We present and assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of
PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in …
PRSs for 28 diseases and 25 quantitative traits being made available on the individuals in …
[HTML][HTML] No phenotypic or genotypic evidence for a link between sleep duration and brain atrophy
Short sleep is held to cause poorer brain health, but is short sleep associated with higher
rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy …
rates of brain structural decline? Analysing 8,153 longitudinal MRIs from 3,893 healthy …
[HTML][HTML] Methylation risk scores are associated with a collection of phenotypes within electronic health record systems
Inference of clinical phenotypes is a fundamental task in precision medicine, and has
therefore been heavily investigated in recent years in the context of electronic health records …
therefore been heavily investigated in recent years in the context of electronic health records …
Genomic innovation in early life cardiovascular disease prevention and treatment
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally.
Although CVD events do not typically manifest until older adulthood, CVD develops …
Although CVD events do not typically manifest until older adulthood, CVD develops …
[HTML][HTML] Clinical utility of polygenic risk scores: a critical 2023 appraisal
S Koch, J Schmidtke, M Krawczak… - Journal of Community …, 2023 - Springer
Since their first appearance in the context of schizophrenia and bipolar disorder in 2009,
polygenic risk scores (PRSs) have been described for a large number of common complex …
polygenic risk scores (PRSs) have been described for a large number of common complex …
Utility of polygenic scores for differentiating diabetes diagnosis among patients with atypical phenotypes of diabetes
Context Misclassification of diabetes type occurs in people with atypical presentations of
type 1 diabetes (T1D) or type 2 diabetes (T2D). Although current clinical guidelines suggest …
type 1 diabetes (T1D) or type 2 diabetes (T2D). Although current clinical guidelines suggest …
[HTML][HTML] An ensemble penalized regression method for multi-ancestry polygenic risk prediction
Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …
the prediction of complex traits and diseases. However, most existing PRS are primarily …
[PDF][PDF] ExPRSweb: An online repository with polygenic risk scores for common health-related exposures
Complex traits are influenced by genetic risk factors, lifestyle, and environmental variables,
so-called exposures. Some exposures, eg, smoking or lipid levels, have common genetic …
so-called exposures. Some exposures, eg, smoking or lipid levels, have common genetic …