Regulation of biological processes by intrinsically chiral engineered materials

B Ma, A Bianco - Nature Reviews Materials, 2023 - nature.com
Chirality has a key role in the synthesis of biomolecules and the development of life.
Although the effects of many chiral molecules or materials on biological processes have …

Physiological barriers and strategies of lipid‐based nanoparticles for nucleic acid drug delivery

M Hu, X Li, Z You, R Cai, C Chen - Advanced Materials, 2024 - Wiley Online Library
Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic
acid drug (NAD) delivery. Although their clinical applications have achieved success, the …

Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona

H Tang, Y Zhang, T Yang, C Wang, Y Zhu, L Qiu… - Nature …, 2023 - nature.com
Nanoparticles (NPs) in biological fluids form a layer of biomolecules known as the protein
corona. The protein corona has been shown to determine the biological identity and in vivo …

[HTML][HTML] In situ analysis of nanoparticle soft corona and dynamic evolution

D Baimanov, J Wang, J Zhang, K Liu, Y Cong… - Nature …, 2022 - nature.com
How soft corona, the protein corona's outer layer, contributes to biological identity of
nanomaterials is largely because capturing protein composition of the soft corona in situ …

Potential health impact of microplastics: a review of environmental distribution, human exposure, and toxic effects

Y Li, L Tao, Q Wang, F Wang, G Li… - Environment & Health, 2023 - ACS Publications
Microplastics are ubiquitous in the global environment. As a typical emerging pollutant, its
potential health hazards have been widely concerning. In this brief paper, we introduce the …

Peripheral nerves directly mediate the transneuronal translocation of silver nanomaterials from the gut to central nervous system

X Wang, X Cui, J Wu, L Bao, Z Tan, C Chen - Science Advances, 2023 - science.org
The blood circulation is considered the only way for the orally administered nanoparticles to
enter the central nervous systems (CNS), whereas non-blood route-mediated nanoparticle …

A targeted exosome therapeutic confers both CfDNA scavenging and macrophage polarization for ameliorating rheumatoid arthritis

Z Wang, C Zhang, J Meng, Z Jiao, W Bao… - Advanced …, 2023 - Wiley Online Library
Only a minority of rheumatoid arthritis (RA) patients achieve disease remission, so the
exploration of additional pathogenic factors and the development of new therapeutics are …

Aging of nanoplastics significantly affects protein corona composition thus enhancing macrophage uptake

T Du, X Yu, S Shao, T Li, S Xu, L Wu - Environmental Science & …, 2023 - ACS Publications
Nanoplastics (NPs), as emerging contaminants, have attracted increasing attention for their
effects on human exposure and potential health risks. The protein corona formed on the …

[HTML][HTML] Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells

Q Wang, Y Liu, H Wang, P Jiang, W Qian… - Nature …, 2022 - nature.com
Abstract DNA methyltransferase 3 A (DNMT3A) is the most frequently mutated gene in acute
myeloid leukemia (AML). Although chemotherapy agents have improved outcomes for …

Mechanistic understanding of protein Corona formation around nanoparticles: old puzzles and new insights

K Nienhaus, GU Nienhaus - Small, 2023 - Wiley Online Library
Although a wide variety of nanoparticles (NPs) have been engineered for use as disease
markers or drug delivery agents, the number of nanomedicines in clinical use has hitherto …