The role of the microbiota in periodontal disease

MA Curtis, PI Diaz, TE Van Dyke - Periodontology 2000, 2020 - Wiley Online Library
The last decade has witnessed unparalleled advances in our understanding of the
complexity of the oral microbiome and the compositional changes that occur in subgingival …

Microbial signatures of health, gingivitis, and periodontitis

L Abusleme, A Hoare, BY Hong, PI Diaz - Periodontology 2000, 2021 - Wiley Online Library
The subgingival crevice harbors diverse microbial communities. Shifts in the composition of
these communities occur with the development of gingivitis and periodontitis, which are …

Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy

G Hajishengallis, T Chavakis… - Periodontology 2000, 2020 - Wiley Online Library
Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions
between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a …

The oral microbiota: dynamic communities and host interactions

RJ Lamont, H Koo, G Hajishengallis - Nature reviews microbiology, 2018 - nature.com
The dynamic and polymicrobial oral microbiome is a direct precursor of diseases such as
dental caries and periodontitis, two of the most prevalent microbially induced disorders …

Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis

AA Abdulkareem, FB Al-Taweel… - Journal of Oral …, 2023 - Taylor & Francis
The primary etiological agent for the initiation and progression of periodontal disease is the
dental plaque biofilm which is an organized aggregation of microorganisms residing within a …

Polymicrobial communities in periodontal disease: Their quasi‐organismal nature and dialogue with the host

G Hajishengallis, RJ Lamont - Periodontology 2000, 2021 - Wiley Online Library
In health, indigenous polymicrobial communities at mucosal surfaces maintain an ecological
balance via both inter‐microbial and host‐microbial interactions that promote their own and …

Oral microbiota and cancer development

H Tuominen, J Rautava - Pathobiology, 2021 - karger.com
Oral microbiota are among the most diverse in the human body. More than 700 species
have been identified in the mouth, and new sequencing methods are allowing us to discover …

Dental biofilm: ecological interactions in health and disease

PD Marsh, E Zaura - Journal of clinical periodontology, 2017 - Wiley Online Library
Background The oral microbiome is diverse and exists as multispecies microbial
communities on oral surfaces in structurally and functionally organized biofilms. Aim To …

A dysbiotic microbiome triggers TH17 cells to mediate oral mucosal immunopathology in mice and humans

N Dutzan, T Kajikawa, L Abusleme… - Science translational …, 2018 - science.org
Periodontitis is one of the most common human inflammatory diseases, yet the mechanisms
that drive immunopathology and could be therapeutically targeted are not well defined …

Integrated hypothesis of dental caries and periodontal diseases

B Nyvad, N Takahashi - Journal of oral microbiology, 2020 - Taylor & Francis
This review considers an integrated hypothesis of dental caries and periodontal diseases
that builds on theoretical ecological principles. The backbone of the hypothesis is based on …