Forsythiae Fructus is a traditional Chinese medicine frequently in clinics. It is extensive in the
treatment of various inflammation-related diseases and is renowned as' the holy medicine of …

Phagocytic activity of glial cells is essential for proper nervous system sculpting,
maintenance of circuitry, and long-term brain health. Glial engulfment of apoptotic cells and …

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
impaired episodic memory and two pathological lesions: amyloid plaques and neurofibrillary …

The P2X7 receptor has been widely studied for its ATP‐induced pro‐inflammatory effect, but
in the absence of a ligand, P2X7 has a second function as a scavenger receptor, which is …

The purinergic pathway mediates both pro-inflammatory and anti-inflammatory responses,
whereas the breakdown of adenosine triphosphate (ATP) is in a critical equilibrium. Under …

The purinergic receptor P2X7 is expressed in neural and immune cells known to be involved
in neurological diseases. Its ligand, ATP, is a signaling molecule that can act as a …

Ischemic stroke is characterized by extensive neuronal loss, glial scar formation, neural
tissue degeneration that leading to profound changes in the extracellular matrix, neuronal …

Approximately 30% of patients with status epilepticus (SE) become refractory to two or more
antiseizure medications (ASMs). There is thus a real need to identify novel targets against …

Background Several lines of evidence suggest that neuroinflammation might be a key
neurobiological mechanism of depression. In particular, the P2X7 receptor (P2X7R), an ATP …

A large body of evidence suggests the involvement of the ATP-gated purinergic receptor
P2X7 (P2X7R) in neurodegenerative diseases, including Alzheimer's disease. While it is …