[HTML][HTML] Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges

L Ferrazzano, M Catani, A Cavazzini, G Martelli… - Green …, 2022 - pubs.rsc.org
Developing greener synthesis processes is an inescapable necessity to transform the
industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable …

[HTML][HTML] Immunomodulatory peptides—A promising source for novel functional food production and drug discovery

M Pavlicevic, N Marmiroli, E Maestri - Peptides, 2022 - Elsevier
Immunomodulatory peptides are a complex class of bioactive peptides that encompasses
substances with different mechanisms of action. Immunomodulatory peptides could also be …

[HTML][HTML] Ramping up antimicrobial peptides against severe acute respiratory syndrome coronavirus-2

SK Ghosh, A Weinberg - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Human-derived antimicrobial peptides (AMPs), such as defensins and cathelicidin LL-37,
are members of the innate immune system and play a crucial role in early pulmonary …

[HTML][HTML] Antimicrobial and amyloidogenic activity of peptides. Can antimicrobial peptides be used against SARS-CoV-2?

SR Kurpe, SY Grishin, AK Surin, AV Panfilov… - International Journal of …, 2020 - mdpi.com
At present, much attention is paid to the use of antimicrobial peptides (AMPs) of natural and
artificial origin to combat pathogens. AMPs have several points that determine their …

[HTML][HTML] Results and prospects of using activator of hematopoietic stem cell differentiation in complex therapy for patients with COVID-19

VK Khavinson, BI Kuznik, SV Trofimova… - Stem Cell Reviews and …, 2021 - Springer
The paper presents the results of a standard and complex treatment method using the
peptide drug thymus thymalin in patients with COVID-19. One of the mechanisms of the …

[HTML][HTML] Peptides regulating proliferative activity and inflammatory pathways in the monocyte/macrophage THP-1 cell line

F Avolio, S Martinotti, VK Khavinson… - International Journal of …, 2022 - mdpi.com
This study evaluates the effects of five different peptides, the Epitalon® tetrapeptide, the
Vilon® dipeptide, the Thymogen® dipeptide, the Thymalin® peptide complex, and the …

[HTML][HTML] In Silico functional and phylogenetic analyses of fungal immunomodulatory proteins of some edible mushrooms

A Ramlal, A Samanta - AMB Express, 2022 - Springer
Mushrooms are a well known source of many bioactive and nutritional compounds with
immense applicability in both the pharmaceutical and food industries. They are widely used …

[HTML][HTML] Co-spray dried nafamostat mesylate with lecithin and mannitol as respirable microparticles for targeted pulmonary delivery: pharmacokinetics and lung …

JH Kang, YJ Kim, MS Yang, DH Shin, DW Kim, IY Park… - Pharmaceutics, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by a new strain of coronavirus called severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading rapidly worldwide …

Techniques assisting peptide vaccine and peptidomimetic design. Sidechain exposure in the SARS-CoV-2 spike glycoprotein

B Robson - Computers in Biology and Medicine, 2021 - Elsevier
The aim of the present study is to discuss the design of peptide vaccines and
peptidomimetics against SARS-COV-2, to develop and apply a method of protein structure …

[HTML][HTML] EDR peptide: possible mechanism of gene expression and protein synthesis regulation involved in the pathogenesis of Alzheimer's disease

V Khavinson, N Linkova, E Kozhevnikova, S Trofimova - Molecules, 2020 - mdpi.com
The EDR peptide (Glu-Asp-Arg) has been previously established to possess neuroprotective
properties. It activates gene expression and synthesis of proteins, involved in maintaining …