Diabetic macular edema: current understanding, molecular mechanisms and therapeutic implications

J Zhang, J Zhang, C Zhang, J Zhang, L Gu, D Luo… - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), with increasing incidence, is the major cause of vision loss and
blindness worldwide in working-age adults. Diabetic macular edema (DME) remains the …

A look into retinal organoids: methods, analytical techniques, and applications

TAV Afanasyeva, JC Corral-Serrano, A Garanto… - Cellular and Molecular …, 2021 - Springer
Inherited retinal diseases (IRDs) cause progressive loss of light-sensitive photoreceptors in
the eye and can lead to blindness. Gene-based therapies for IRDs have shown remarkable …

Causality of genetically determined metabolites on anxiety disorders: a two-sample Mendelian randomization study

G Xiao, Q He, L Liu, T Zhang, M Zhou, X Li… - Journal of translational …, 2022 - Springer
Background Although anxiety disorders are one of the most prevalent mental disorders, their
underlying biological mechanisms have not yet been fully elucidated. In recent years …

Genetically predicted 486 blood metabolites in relation to risk of colorectal cancer: a Mendelian randomization study

Z Yun, Z Guo, X Li, Y Shen, M Nan, Q Dong… - Cancer …, 2023 - Wiley Online Library
Background Metabolic disorders are a hallmark feature of cancer. However, the evidence for
the causality of circulating metabolites to promote or prevent colorectal cancer (CRC) is still …

Metabolomics in diabetic retinopathy: from potential biomarkers to molecular basis of oxidative stress

Q Jian, Y Wu, F Zhang - Cells, 2022 - mdpi.com
Diabetic retinopathy (DR), the leading cause of blindness in working-age adults, is one of
the most common complications of diabetes mellitus (DM) featured by metabolic disorders …

Cellular mechanisms of hereditary photoreceptor degeneration–Focus on cGMP

M Power, S Das, K Schütze, V Marigo, P Ekström… - Progress in Retinal and …, 2020 - Elsevier
The cellular mechanisms underlying hereditary photoreceptor degeneration are still poorly
understood, a problem that is exacerbated by the enormous genetic heterogeneity of this …

Regulation of the one carbon folate cycle as a shared metabolic signature of longevity

A Annibal, RG Tharyan, MF Schonewolff, H Tam… - Nature …, 2021 - nature.com
The metabolome represents a complex network of biological events that reflects the
physiologic state of the organism in health and disease. Additionally, specific metabolites …

[HTML][HTML] Integrating metabolomics, genomics, and disease pathways in age-related macular degeneration: the EYE-RISK consortium

IE Acar, L Lores-Motta, JM Colijn, MA Meester-Smoor… - Ophthalmology, 2020 - Elsevier
Purpose The current study aimed to identify metabolites associated with age-related
macular degeneration (AMD) by performing the largest metabolome association analysis in …

Amino acids metabolism in retinopathy: from clinical and basic research perspective

M Xia, F Zhang - Metabolites, 2022 - mdpi.com
Retinopathy, including age-related macular degeneration (AMD), diabetic retinopathy (DR),
and retinopathy of prematurity (ROP), are the leading cause of blindness among seniors …

Neuron devices: emerging prospects in neural interfaces and recognition

Y Wang, S Liu, H Wang, Y Zhao… - Microsystems & …, 2022 - nature.com
Neuron interface devices can be used to explore the relationships between neuron firing
and synaptic transmission, as well as to diagnose and treat neurological disorders, such as …