Unravelling the epigenome of myelodysplastic syndrome: Diagnosis, prognosis, and response to therapy

DR Bond, HJ Lee, AK Enjeti - Cancers, 2020 - mdpi.com
Simple Summary Myelodysplastic syndrome (MDS) is a type of blood cancer that mostly
affects older individuals. Invasive tests to obtain bone samples are used to diagnose MDS …

Medulloblastoma uses GABA transaminase to survive in the cerebrospinal fluid microenvironment and promote leptomeningeal dissemination

V Martirosian, K Deshpande, H Zhou, K Shen, K Smith… - Cell reports, 2021 - cell.com
Medulloblastoma (MB) is a malignant pediatric brain tumor arising in the cerebellum.
Although abnormal GABAergic receptor activation has been described in MB, studies have …

EARN: an ensemble machine learning algorithm to predict driver genes in metastatic breast cancer

L Mirsadeghi, R Haji Hosseini… - BMC Medical …, 2021 - Springer
Background Today, there are a lot of markers on the prognosis and diagnosis of complex
diseases such as primary breast cancer. However, our understanding of the drivers that …

Genome-wide methylation sequencing identifies progression-related epigenetic drivers in myelodysplastic syndromes

J Zhou, T Zhang, Z Xu, Z Deng, YU Gu, J Ma… - Cell Death & …, 2020 - nature.com
The potential mechanism of myelodysplastic syndromes (MDS) progressing to acute
myeloid leukemia (AML) remains poorly elucidated. It has been proved that epigenetic …

Identification and validation of prognosis‐related DLX5 methylation as an epigenetic driver in myeloid neoplasms

T Zhang, Z Xu, Y Gu, X Wen, J Ma… - Clinical and …, 2020 - Wiley Online Library
The deregulated DLX gene family members DLX1/2/3/4/5/6 (DLXs) caused by DNA
methylation has been demonstrated in various cancers with therapeutic target value …

Genome-wide analysis toward the epigenetic aetiology of myelodysplastic syndrome disease progression and pharmacoepigenomic basis of hypomethylating agents …

S Siamoglou, R Boers, M Koromina, J Boers, A Tsironi… - Human Genomics, 2023 - Springer
Myelodysplastic syndromes (MDS) consist of a group of hematological malignancies
characterized by ineffective hematopoiesis, cytogenetic abnormalities, and often a high risk …

Dietary flaxseed oil and vitamin E improve semen quality via propionic acid metabolism

C Yuan, K Zhang, Z Wang, X Ma, H Liu… - Frontiers in …, 2023 - frontiersin.org
Introduction Flaxseed oil (FO) and vitamin E (VE) both have antioxidant effects on sperm.
The present study investigated the effects of dietary supplementation with FO and/or VE on …

A targeted bioinformatics assessment of adrenocortical carcinoma reveals prognostic implications of GABA system gene expression

EL Knott, NJ Leidenheimer - International journal of molecular sciences, 2020 - mdpi.com
Adrenocortical carcinoma (ACC) is a rare but deadly cancer for which few treatments exist.
Here, we have undertaken a targeted bioinformatics study of The Cancer Genome Atlas …

Regulation of gamma-aminobutyric acid transaminase expression and its clinical significance in hepatocellular carcinoma

X Gao, X Jia, M Xu, J Xiang, J Lei, Y Li, Y Lu… - Frontiers in …, 2022 - frontiersin.org
Background Gamma-aminobutyric acid transaminase (ABAT) catalyzes the conversion of
gamma-aminobutyric acid (GABA) into succinic semialdehyde. Although some evidence …

Role of 4‑aminobutyrate aminotransferase (ABAT) and the lncRNA co‑expression network in the development of myelodysplastic syndrome Corrigendum in/10.3892 …

Y Chen, G Zhao, N Li, Z Luo, X Wang… - Oncology …, 2019 - spandidos-publications.com
IncRNAs play an important role in the regulation of gene expression. The present study
profiled differentially expressed lncRNAs (DELs) and mRNAs (DEMs) in myelodysplastic …