Pancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest malignancies,
with dismal survival rates and extremely prevalent chemoresistance. Gemcitabine is one of …

Pancreatic cancer is one of the most malignant tumors with increased incidence rate. The
effect of surgery combined with chemoradiotherapy on survival of patients is unsatisfactory …

Pancreatic ductal adenocarcinoma (PDAC) is a gastrointestinal malignancy with a dismal
clinical outcome. Accumulating evidence suggests that activated pancreatic stellate cells …

Fibrosis is the unrelenting deposition of excessively large amounts of insoluble interstitial
collagen due to profound matrigenic activities of wound-associated myofibroblasts during …

The versatility and nanoscale size have helped nanoparticles (NPs) improve the efficacy of
conventional cancer immunotherapy and opened up exciting approaches to combat cancer …

Pancreatic ductal adenocarcinoma (PDA) is characterized by an extensive fibroinflammatory
microenvironment that accumulates from the onset of disease progression. Cancer …

Background and aims The crosstalk between cancer stem cells (CSCs) and their niche is
required for the maintenance of stem cell-like phenotypes of CSCs. Here, we identified E26 …

Abstract Background Pancreatic stellate cells (PSCs) play key roles in the pancreatic tumor
microenvironment and are considered to contribute to chemoresistance. PSCs can …

Nanozymes have limited applications in clinical practice due to issues relating to their safety,
stability, biocompatibility, and relatively low catalytic activity in the tumor microenvironment …

Hypoxia is involved in the development of pancreatic cancer (PC). The responses of hypoxia‐
associated genes and their regulated mechanisms are largely unknown. In this study …