Neonatal sepsis accounts for significant morbidity and mortality, particularly among
premature infants in the Neonatal Intensive Care Unit. Abnormal vital sign patterns serve as …

Oxygen is the final electron acceptor in aerobic respiration, and a lack of oxygen can result
in bioenergetic failure and cell death. Thus, administration of supplemental concentrations of …

We have developed and optimized an imaging system to study and improve the detection of
brain hemorrhage and to quantify oxygenation. Since this system is intended to be used for …

Cerebrovascular reactivity defines the ability of the cerebral vasculature to regulate its
resistance in response to both local and systemic factors to ensure an adequate cerebral …

Importance Repeated transfusions in preterm neonates with anemia of prematurity replace
fetal hemoglobin (HbF) with adult Hb (HbA), which has a low oxygen affinity. The reduction …

Cerebrovascular pressure autoregulation promotes stable cerebral blood flow (CBF) across
a range of arterial blood pressures. Cerebral autoregulation (CA) is a developmental …

This review examines advancements in the measurement and imaging of oxidized
cytochrome-c-oxidase (oxCCO) using near-infrared spectroscopy (NIRS) in humans since …

Neonatology has experienced a significant reduction in mortality rates of the preterm
population and critically ill infants over the last few decades. Now, the emphasis is directed …

Timely detection and monitoring of acute brain injury in children is essential to mitigate
causes of injury and prevent secondary insults. Increasing survival in critically ill children …

Red blood cell (RBC) transfusion is a common clinical intervention used to treat patients with
acute and chronic anemia. The decision to transfuse RBCs in the acute setting is based on …