A systematic review of the valproic-acid-induced rodent model of autism

D Chaliha, M Albrecht, M Vaccarezza… - Developmental …, 2020 - karger.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by
repetitive behaviours, cognitive rigidity/inflexibility, and social-affective impairment …

Prenatal exposure to valproic acid affects microglia and synaptic ultrastructure in a brain-region-specific manner in young-adult male rats: relevance to autism …

M Gąssowska-Dobrowolska, M Cieślik… - International journal of …, 2020 - mdpi.com
Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental
conditions categorized as synaptopathies. Environmental risk factors contribute to ASD …

Social behavior, neuroimmune markers and glutamic acid decarboxylase levels in a rat model of valproic acid-induced autism

TT Win-Shwe, NC Nway, M Imai, TT Lwin… - The Journal of …, 2018 - jstage.jst.go.jp
Autism is a complex neurodevelopmental disorder characterized by impaired social
communication and social interactions, and repetitive behaviors. The etiology of autism …

Group I and group II metabotropic glutamate receptors are upregulated in the synapses of infant rats prenatally exposed to valproic acid

S D'Antoni, S Schiavi, V Buzzelli, S Giuffrida, A Feo… - …, 2023 - Springer
Rationale Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized
by impaired social interaction and restricted/stereotyped behavior. Prenatal exposure to …

Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamatergic protein expression in mouse offspring of both …

E González-Madrid, MA Rangel-Ramírez… - Frontiers in …, 2024 - frontiersin.org
Background The prevalence of autism spectrum disorder (ASD) has significantly risen in the
past three decades, prompting researchers to explore the potential contributions of …

Effects of PM2.5 and gases exposure during prenatal and early-life on autism–like phenotypes in male rat offspring

B Emam, A Shahsavani, F Khodagholi… - Particle and fibre …, 2020 - Springer
Background Epidemiological studies have reported associations between elevated air
pollution and autism spectrum disorders (ASD). However, we hypothesized that exposure to …

[HTML][HTML] Extracts from the edible insects Gryllus bimaculatus and Oxya chinensis sinuosa as an effective postnatal therapy for improving autistic behavior through …

NB Tran, H Lee, SJ Lee - Journal of Functional Foods, 2023 - Elsevier
In the food resource crisis caused by global warming, interest in edible insects with high
medicinal value in various diseases as well as nutritional value is increasing. This study …

Inhibition of the ERK1/2 Phosphorylation by Dextromethorphan Protects against Core Autistic Symptoms in VPA Induced Autistic Rats: In Silico and in Vivo Drug …

R Singla, A Mishra, R Joshi, R Kumar… - ACS Chemical …, 2021 - ACS Publications
The imbalance between excitatory and inhibitory neurotransmitters is explicitly related to the
pathophysiology of autism spectrum disorder (ASD). The role of an NMDA receptor …

Granulocyte colony-stimulating factor improved core symptoms of autism spectrum disorder via modulating glutamatergic receptors in the prefrontal cortex and …

A Mishra, R Singla, R Kumar, AR Sharma… - ACS Chemical …, 2022 - ACS Publications
Chronic neuroinflammation-induced anomalous glutamate receptor activation has been
identified as one of the important factors in the pathogenesis of autism spectrum disorder …

Mycobacterium tuberculosis-Induced Maternal Immune Activation Promotes Autism-Like Phenotype in Infected Mice Offspring

W Manjeese, NE Mvubu, AJC Steyn… - International Journal of …, 2021 - mdpi.com
The maternal system's exposure to pathogens during pregnancy influences fetal brain
development causing a persistent inflammation characterized by elevated pro-inflammatory …