Effects of arachidonic acid metabolites on cardiovascular health and disease
Arachidonic acid (AA) is an essential fatty acid that is released by phospholipids in cell
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …
membranes and metabolized by cyclooxygenase (COX), cytochrome P450 (CYP) enzymes …
Involvement of fatty acids and their metabolites in the development of inflammation in atherosclerosis
S Kotlyarov, A Kotlyarova - International journal of molecular sciences, 2022 - mdpi.com
Despite all the advances of modern medicine, atherosclerosis continues to be one of the
most important medical and social problems. Atherosclerosis is the cause of several …
most important medical and social problems. Atherosclerosis is the cause of several …
Vascular actions of 20-HETE
hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic acid that exhibits a
myriad of biological effects in the vascular system. This review discusses the current …
myriad of biological effects in the vascular system. This review discusses the current …
20-HETE and blood pressure regulation: clinical implications
Hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE) is a cytochrome P450 (CYP)–derived
omega-hydroxylation metabolite of arachidonic acid. 20-HETE has been shown to play a …
omega-hydroxylation metabolite of arachidonic acid. 20-HETE has been shown to play a …
20-HETE in the regulation of vascular and cardiac function
P Rocic, ML Schwartzman - Pharmacology & therapeutics, 2018 - Elsevier
HETE, the ω-hydroxylation product of arachidonic acid catalyzed by enzymes of the
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …
cytochrome P450 (CYP) 4A and 4F gene families, is a bioactive lipid mediator with potent …
[HTML][HTML] Molecular mechanisms and cell signaling of 20-hydroxyeicosatetraenoic acid in vascular pathophysiology
Cytochrome P450s enzymes catalyze the metabolism of arachidonic acid to
epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and …
epoxyeicosatrienoic acids (EETs), dihydroxyeicosatetraenoic acid and …
[HTML][HTML] Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice
Abstract Renal cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) regulate
sodium transport and blood pressure. Although endothelial CYP-derived EETs are potent …
sodium transport and blood pressure. Although endothelial CYP-derived EETs are potent …
The role of 20-HETE in cardiovascular diseases and its risk factors
M Waldman, SJ Peterson, M Arad… - Prostaglandins & other …, 2016 - Elsevier
Arachidonic acid (AA) is metabolized in mammals by enzymes of the CYP4A and 4F families
to 20-hydroxyeicosatetraeonic acid (20-HETE) which plays an important role in the …
to 20-hydroxyeicosatetraeonic acid (20-HETE) which plays an important role in the …
Cytochrome p450 enzymes in the bioactivation of polyunsaturated Fatty acids and their role in cardiovascular disease
C Westphal, A Konkel, WH Schunck - Monooxygenase, Peroxidase and …, 2015 - Springer
Various members of the cytochrome P450 (CYP) superfamily have the capacity of
metabolizing omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFAs). In …
metabolizing omega-6 and omega-3 polyunsaturated fatty acids (n-6 and n-3 PUFAs). In …
The role of 20-HETE in androgen-mediated hypertension
CC Wu, ML Schwartzman - Prostaglandins & other lipid mediators, 2011 - Elsevier
Androgen plays an important role in blood pressure regulation. Epidemiological studies
have shown that men have a higher prevalence for developing hypertension than aged …
have shown that men have a higher prevalence for developing hypertension than aged …