A genomic mutational constraint map using variation in 76,156 human genomes

S Chen, LC Francioli, JK Goodrich, RL Collins, M Kanai… - Nature, 2024 - nature.com
The depletion of disruptive variation caused by purifying natural selection (constraint) has
been widely used to investigate protein-coding genes underlying human disorders,,–, but …
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The depletion of disruptive variation caused by purifying natural selection (constraint) has
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A genomic mutational constraint map using variation in 76,156 human genomes

Genome Aggregation Database Consortium - Nature, 2024 - researchwithrutgers.com
The depletion of disruptive variation caused by purifying natural selection (constraint) has
been widely used to investigate protein-coding genes underlying human disorders 1–4, but …

A genomic mutational constraint map using variation in 76,156 human genomes

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The depletion of disruptive variation caused by purifying natural selection (constraint) has
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A genomic mutational constraint map using variation in 76,156 human genomes

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The depletion of disruptive variation caused by purifying natural selection (constraint) has
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