… Definitive efficacy has been demonstrated in advanced … basis for the recent regulatory
approvals for these indications. This article summarizes the discovery and development of sunitinib…

… In conclusion, sunitinib is an orally bioavailable small molecule that inhibits members of
the split-kinase domain family of RTKs, including VEGFR and PDGFR, and signaling through …

… On the basis of its tolerable toxicity and preclinical efficacy, clinical development of sunitinib
was granted. Initial trials were conducted in healthy volunteers and the results showed that a …

… efficacy of sunitinib and minimize adverse events. Here, we focus on new insights into
molecular mechanisms that may mediate sunitinib-… about the molecular basis of sunitinib side …

… The efficacy and safety of sunitinib in patients with imatinibresistant GIST was explored in an
open-… [74,75] The efficacy of delayed sunitinib treatment in improving median time to tumor …

… of treatment with a TKI, sunitinib (SU11248), with … ) Sunitinib is a small molecule that blocks
multiple tyrosine kinase receptors (thus, it is grouped into tyrosine kinase inhibitors). Sunitinib …

… understanding of the molecular basis and mechanisms of action … explain the molecular
mechanisms whereby sunitinib could elicit … Molecular basis for sunitinib efficacy and future clinical …

… discuss molecular mechanisms of resistance to sunitinib and the … and resistance to treatment
with sunitinib, and elaborate on … that pazopanib has similar efficacy as sunitinib, but with a …

… This suggests a loss of SM efficacy over time and a possible time-developing shift from
one … Cumulatively, our molecular data provide evidence of the activity of SM both in case of …

… Sunitinib is an oral multikinase inhibitor that blocks the … These attributes have proven to be
efficacious in the treatment … Clinical trials are underway to determine the efficacy of sunitinib in …