From molecular signatures to predictive biomarkers: modeling disease pathophysiology and drug mechanism of action

A Heinzel, P Perco, G Mayer, R Oberbauer… - Frontiers in cell and …, 2014 - frontiersin.org
molecular pathway map indicates involvement of multiple molecular mechanisms, and selected
biomarker … are identified for specific molecular processes. Selective interference of drug …

[HTML][HTML] Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers

J Jin, Y Xie, JS Zhang, JQ Wang, SJ Dai, W He… - Drug Resistance …, 2023 - Elsevier
… drug resistance mechanisms. In this review, we discuss: 1) molecular mechanisms of …
overcome sunitinib resistance and 3) potential predictive biomarkers of sunitinib resistance. …

[HTML][HTML] New frontiers against sorafenib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers

Y He, Y Luo, L Huang, D Zhang, X Wang, J Ji… - Pharmacological …, 2021 - Elsevier
… So far, the molecular mechanism of sorafenib resistance in RCC needs to be … mechanisms
of sorafenib resistance in RCC. Herein this review will focus on the molecular mechanisms of …

Prognostic and predictive biomarkers: tools in personalized oncology

E Nalejska, E Mączyńska… - Molecular diagnosis & …, 2014 - Springer
Molecular mechanisms of neoplasia involve a great number of genetic aberrations and
abnormalities [1], but a small part of them are found in all tumor types, which may be of key …

[HTML][HTML] Cancer diagnostic and predictive biomarkers

FM Buonaguro, D Pauza, ML Tornesello… - BioMed research …, 2014 - ncbi.nlm.nih.gov
… The whole field is in a current turmoil, and this specific issue, focused on the clinical
validation of newly identified biomarkers, has been able to bridge molecular mechanisms with …

Predictive biomarkers of colorectal cancer

D Ding, S Han, H Zhang, Y He, Y Li - Computational biology and chemistry, 2019 - Elsevier
… Then biological functions and molecular mechanisms of the candidate biomarkers of
colorectal cancer are inferred utilizing multi-source biological knowledge and literature mining. …

From Biomarkers to the Molecular Mechanism of Preeclampsia—A Comprehensive Literature Review

M Rybak-Krzyszkowska, J Staniczek… - … Journal of Molecular …, 2023 - mdpi.com
… in predicting different PE … predictive biomarkers and their molecular mechanisms, improving
screening efficacy and distinguishing between early-onset and late-onset PE. Biomarker

Mechanism-derived gene expression signatures and predictive biomarkers in clinical oncology

ET Liu - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences
mechanism-driven approach to prognostic biomarker discovery on a genome scale. Second,
by focusing on biological mechanisms … Mechanistically derived candidate biomarkers have …

Predictive biomarkers and mechanisms underlying resistance to PD1/PD-L1 blockade cancer immunotherapy

D Ren, Y Hua, B Yu, X Ye, Z He, C Li, J Wang, Y Mo… - Molecular cancer, 2020 - Springer
… for predicting the efficacy of PD-1/PD-L1 blockade therapy. Furthermore, we explore the
mechanisms … The predictive indicators, resistance mechanisms, and combination therapies …

Predictive biomarkers in renal cell cancer: insights in drug resistance mechanisms

JC van der Mijn, JW Mier, HJ Broxterman… - Drug Resistance …, 2014 - Elsevier
… Since hypertension does seem to be a measure of efficient VEGF blockade based on the
molecular mechanism described above, these results suggest that VEGF independent …